Wheezing in children

Al-Shamrani, Abdullah; Bagais, Khalid; Alenazi, Ayed; Alqwaiee, Mansour M; Alharbi‎, Abdulrahman

doi:10.1016/j.ijpam.2019.02.003

Cited by 26 publications

(31 citation statements)

References 93 publications

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“…Several phenotypes are considered as the debut of the disease. The proportion of such children ranges from 13% to 16% according to various sources [6,[22][23][24]. This fact has been confirmed in our study.…”

Section: Discussionsupporting

confidence: 88%

“…The debut of the disease takes place in childhood [3][4][5]. Accurate diagnosis of asthma in this age cohort may represent a significant clinical challenge [1,3,6]. Firstly, the clinical signs of wheezing in children can be caused by many diseases, among which, besides asthma, there are hereditary and birth defects with metabolic processes, pathology of the gastroesophageal zone, congenital and acquired defects of the heart and main vessels and many others that should be included in the differential diagnostics [3][4][5]7].…”

Section: Introductionmentioning

confidence: 99%

“…Secondly, in children under 6 years of age, there are limitations in the study of lung function. Therefore, in this cohort, diagnosis is based mainly on clinical and anamnestic data [6][7][8]. So, the global medical problem is to expand the diagnostic possibilities of early detection of asthma in children.…”

Section: Introductionmentioning

confidence: 99%

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Are Level of IL-13 and IL-4 Predictive for Formation of Chronic Inflammation in Children with Asthma?

Makieieva

Vasylchenko

Tsymbal

2020

Advances in Respiratory Medicine

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Introduction: Asthma diagnosis in young children may represent a clinical challenge. There are no standard prognostic and diagnostic methods. The aim of the study was to evaluate the clinical and prognostic assessment of IL-4 and IL-13 concentrations in children with recurrent wheezing. Material and methods: The study included 96 children with recurrent wheezing. 81 patients were diagnosed as transient wheezing, 15 patients with asthma, and 25 healthy children were selected as controls. The concentrations of IL-4 and IL-13 were analyzed in exhaled breath condensate (EBC) using an enzyme-linked immunosorbent assay (ELISA). Data analysis was performed using Statsoft Statistica Version 8 (Tulsa, OK) and the statistical program MedCalc version 17.2. Results: Both IL-4 and IL-13 concentrations were significantly higher in DDA (21.13 pg/mL, 26.13 pg/mL, respectively) and TW (13.86 pg/mL, 18.3 pg/mL, respectively) groups as compared to healthy controls (3.37 pg/mL, 16.35 pg/mL, respectively; p < 0.001), and the highest rates were observed in children with diagnosed asthma (p < 0.001, DDW vs TW, respectively). IL-4 concentration higher than 18.45 pg/mL (with sensitivity 86.7% and specificity 80%) and IL-13 concentration higher than 20.17 pg/ /mL (with sensitivity 100% and specificity 76.7%) in EBC in children with wheezing recurrence can be considered as a possible predictor of asthma development. Conclusions: The concentration of the anti-inflammatory cytokines IL-4 and IL-13 were significantly increased in children with recurrent wheezing and the highest rates were found in asthma developing children. The concentrations of IL-4 and IL-13 in children with wheezing can be considered as a possible predictor of asthma development.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Are Level of IL-13 and IL-4 Predictive for Formation of Chronic Inflammation in Children with Asthma?

Makieieva

Vasylchenko

Tsymbal

2020

Advances in Respiratory Medicine

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“…Approximately one-third of children have at least one episode of wheeze before their third birthday. [ 302 303 ] In preschool children, asthma diagnosis and management differ from that of older children and adolescent in many ways. Early childhood wheezing can evolve to different asthma phenotypes that can have variable response to standard therapy.…”

Section: Section 9: Management Of Asthma In Childrenmentioning

confidence: 99%

The Saudi Initiative for Asthma - 2021 Update: Guidelines for the diagnosis and management of asthma in adults and children

et al. 2021

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The Saudi Initiative for Asthma 2021 (SINA-2021) is the fifth version of asthma guidelines for the diagnosis and management of asthma for adults and children, which is developed by the SINA group, a subsidiary of the Saudi Thoracic Society. The main objective of the SINA is to have guidelines that are up to date, simple to understand, and easy to use by healthcare workers dealing with asthma patients. To facilitate achieving the goals of asthma management, the SINA panel approach is mainly based on the assessment of symptom control and risk for both adults and children. The approach to asthma management is aligned for age groups: adults, adolescents, children aged 5–12 years, and children aged less than 5 years. SINA guidelines have focused more on personalized approaches reflecting better understanding of disease heterogeneity with the integration of recommendations related to biologic agents, evidence-based updates on treatment, and the role of immunotherapy in management. Medication appendix has also been updated with the addition of recent evidence, new indications for existing medication, and new medications. The guidelines are constructed based on the available evidence, local literature, and the current situation at national and regional levels. There is also an emphasis on patient–doctor partnership in the management that also includes a self-management plan.

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“…Possible future areas of use may be the adjustment of anti-inflammatory therapy in asthmatic patients and children suffering from various wheezing phenotypes in particular if they are symptomatic at night [ 44 ]. Also, treatment optimization in patients with cystic fibrosis and the diagnosis of patients suspected to suffer from psychogenic cough might be possible.…”

Section: Discussionmentioning

confidence: 99%

Wheeze and cough measurements at night in children with respiratory symptoms

et al. 2020

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Background Nocturnal cough and wheeze are important symptoms when diagnosing any respiratory disease in a child, but objective measurements of these symptoms are not performed. Methods The aim of our study was to analyze the use of an automated detection system to assess breath sounds objectively in comparison to cough and wheeze questionnaires and to evaluate its feasibility in clinical practice. Results Forty-nine recordings of thirty-nine children were processed (asthma n = 13; cystic fibrosis n = 2; pneumonia n = 5; suspicion of habit cough n = 7; prolonged, recurrent or chronic cough n = 13), and cough and asthma scores were compared to the objective nocturnal recordings. Time for audio-validation of recordings took between 2 and 40 min (mean: 14.22 min, (SD): 10.72). Accuracy of the automated measurement was higher for cough than for wheezing sounds. Nocturnal cough readings but not wheeze readings correlated with some of the corresponding scores. Conclusion To our knowledge this is the first study using a new device to assess nocturnal cough and obstructive breath sounds objectively in children with a wide variety of respiratory diseases. The assessment proved user friendly. We obtained additional information on nighttime symptoms, which would otherwise have remained obscure. Further studies to assess possible diagnostic and therapeutic benefits of this device are needed.

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Wheezing in children

Cited by 26 publications

References 93 publications

Are Level of IL-13 and IL-4 Predictive for Formation of Chronic Inflammation in Children with Asthma?

Are Level of IL-13 and IL-4 Predictive for Formation of Chronic Inflammation in Children with Asthma?

The Saudi Initiative for Asthma - 2021 Update: Guidelines for the diagnosis and management of asthma in adults and children

Wheeze and cough measurements at night in children with respiratory symptoms

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