Wheeze associated with prenatal tobacco smoke exposure: a prospective, longitudinal study

Lux, Andrew; Henderson, John; Pocock, Stuart J.

doi:10.1136/adc.83.4.307

Cited by 103 publications

(68 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Comparative or secular studies are warranted in future investigations. Younger subjects and boys had a higher rate of physician-diagnosed asthma, which was consistent with other studies, 8,9,12,14,21,34,35 and the level of parental education and number of siblings were associated with the occurrence of childhood asthma. Parents with a higher education level and fewer children were more anxious about the specific health condition of their children; therefore, these children would be more likely to receive a diagnosis of asthma.…”

Section: Discussionsupporting

confidence: 81%

“…Although not statically significant, maternal smoking during pregnancy was also a positive predictor of asthma in our population, which was consistent with the finding in a recent report from the Avon Longitudinal Study of Pregnancy and Childhood. 12 We also treated it as a confounder, which was adjusted in the following multiple regression analysis. Daily cigarette consumption in families and incense burning at home showed negative effects to the occurrence of childhood asthma (Table 1), which were consistent with recent international studies.…”

Section: E392mentioning

confidence: 99%

See 1 more Smart Citation

Indoor and Outdoor Environmental Exposures, Parental Atopy, and Physician-Diagnosed Asthma in Taiwanese Schoolchildren

et al. 2003

View full text Add to dashboard Cite

ABSTRACT. Objective. Parental atopy and environmental exposures are recognized risk factors for childhood asthma. However, the relative contributions of specific risk factors and the overall contributions of indoor and outdoor exposures remain unexplored. This study was undertaken to identify risk factors, estimate the population attributable risk of each exposure, and compare the data for boys versus girls for physician-diagnosed asthma in Taiwanese schoolchildren.Methods. During a February to June 2001 cross-sectional national survey, 35 036 6-to 15-year-old schoolchildren were chosen from 22 elementary and 22 middle schools located within 1-km catchment areas of 22 airmonitoring stations in Taiwan. The main outcome measure was physician-diagnosed asthma, as reported by the parents. We investigated hereditary and indoor and outdoor environmental factors for childhood asthma by questionnaire. The adjusted prevalences of questionnaire-determined outdoor indicators were also compared with air-monitoring data.Results. Outdoor air pollutants were associated with parent-reported perceived ambient air pollution. Physician-diagnosed asthma was reported for 8.1% of the boys (1330 of 16 441) and 5.6% of the girls (894 of 16 056). The risk of physician-diagnosed asthma was significantly associated with parental atopy and perceived ambient air pollution in both sexes. A sthma is the single most common chronic childhood disease in developed nations, 1,2 and its prevalence and severity have been reported as increasing in many countries. [3][4][5][6] The changing pattern of the disease has not been fully explained, in part because of an incomplete understanding of its pathogenesis. The change has been too rapid to be accounted for by changes in gene frequencies. It is also unlikely that the increase can be totally accounted for by changes in either clinical diagnostic patterns or increased recognition of asthma symptoms by the general population. 7 This does, however, suggest a role for environmental exposures in the cause of this evolving epidemic. 8 Many factors have been proved to be associated with the prevalence and/or attacks of asthma, including personal factors (smoking habits, genetics, age, sex, nutritional status, number of siblings, coexisting lung disease, lifestyle, allergy status, family history, and occupation) and environmental stimuli (house dust, animal danders, molds, cockroach infestation, occupational exposure, environmental tobacco smoke, indoor/outdoor air pollution, cooking fumes, aeroallergens, and climate). 9 -29 Both genetic and environmental factors are believed to contribute to the relationship. However, epidemiologic evidence concerning different effects in boys and girls in relationships between environmental exposures and childhood asthma was insufficient and warranted additional investigations.The first aim of this study was to investigate the relationship between physician-diagnosed asthma and selected risk factors in a population-based sample of 6-to 15-year-old elementary-and middleschool...

show abstract

Section: Discussionsupporting

confidence: 81%

Section: E392mentioning

confidence: 99%

Indoor and Outdoor Environmental Exposures, Parental Atopy, and Physician-Diagnosed Asthma in Taiwanese Schoolchildren

et al. 2003

View full text Add to dashboard Cite

show abstract

“…It might be argued that the follow-up was not continued for long enough to recognize postnatal effects, but significant associations were observed with other factors that have been associated with increased risk of wheezing and an independent effect of postnatal ETS exposure was found in the Czech population. The follow-up of the Avon population has been continued, and recent studies have demonstrated independent effects of prenatal and postnatal smoking on wheeze during later childhood [24]. The observation of a postnatal but not a prenatal effect of smoking on infant wheeze in the Czech population is largely unexplained and further studies using objective measurements of nicotine metabolites may help to elucidate the mechanisms for this finding.…”

Section: Discussionmentioning

confidence: 99%

Pre- and postnatal parental smoking and wheeze in infancy: cross cultural differences

Henderson

Sherriff²,

Northstone³

et al. 2001

Eur Respir J

View full text Add to dashboard Cite

In longitudinal cohort studies, the relationships between prenatal and postnatal tobacco smoke exposure and infant wheezing illnesses were compared in two geographically defined populations in Avon, UK and Brno and Znojmo in the South Moravian Region of the Czech Republic.Pregnant females living in defined regions and with expected dates of delivery between defined dates were recruited. Females completed self-report questionnaires during pregnancy and when their infant was 6 months old. For this analysis, responses to questions about smoking during pregnancy, environmental tobacco smoke (ETS) exposure and reported wheezing illnesses of infants at 6 months after birth were used. Odds ratios for wheeze in relation to the smoking variables were calculated with adjustment for potential confounding effects.The prevalence of smoking during pregnancy was higher in Avon (17.5%) than the Czech Republic (7.1%). Exposure of infants to ETS during the first 6 months after birth was also reported to be higher in Avon (35.5%) than the Czech Republic (9.7%). The prevalence of reported wheezing by 6 months of age was 21.4% in Avon and 10.3% in Brno and Znojmo. In Avon, there was a significant relationship between infant wheeze and maternal smoking during pregnancy (odds ratio (95% confidence interval) 1.30 (1.09-1.56), p=0.004) but not with environmental exposure after birth (1.11 (0.98-1.25)). In contrast, in Brno and Znojmo in the Czech Republic, there was a significant relationship between infant wheeze and ETS exposure (1.66 (1.17-2.36), p=0.04) but not with maternal smoking during pregnancy (0.99 (0.64-1.55)).This study demonstrated an apparent difference in the associations between prenatal and postnatal tobacco smoke exposure and infant wheezing illnesses in two populations with different smoking prevalence. The relationships were independent of a number of potential confounding variables that have been associated with infant wheezing. Possible explanations of these observations include dose-related effects of prenatal and postnatal tobacco smoke exposure of infants.

show abstract

“…A further potential 28 articles were identified after reference list review and 9 identified as potentially eligible articles from the previous meta-analyses. 1 After excluding studies that presented similar outcomes from the same cohorts, there were 70 articles (representing 71 studies) eligible for inclusion in the systematic review and meta-analyses (Fig 1, Supplemental Tables 3 [in-cluded studies] and 4[excluded studies] [8][9][10][11][12][13][14][15][16] ). Thirty-two of the 71 studies assessed asthma as an outcome (46%), 31 assessed wheeze (44%), and 8 assessed both asthma and wheeze (11%).…”

Section: Resultsmentioning

confidence: 99%

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

et al. 2012

View full text Add to dashboard Cite

OBJECTIVES: Exposure to passive smoke is a common and avoidable risk factor for wheeze and asthma in children. Substantial growth in the prospective cohort study evidence base provides an opportunity to generate new and more detailed estimates of the magnitude of the effect. A systematic review and meta-analysis was conducted to provide estimates of the prospective effect of smoking by parents or household members on the risk of wheeze and asthma at different stages of childhood. METHODS:We systematically searched Medline, Embase, and conference abstracts to identify cohort studies of the incidence of asthma or wheeze in relation to exposure to prenatal or postnatal maternal, paternal, or household smoking in subjects aged up to 18 years old. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by using random effects model. RESULTS:We identified 79 prospective studies. Exposure to pre-or postnatal passive smoke exposure was associated with a 30% to 70% increased risk of incident wheezing (strongest effect from postnatal maternal smoking on wheeze in children aged #2 years, OR = 1.70, 95% CI = 1.24-2.35, 4 studies) and a 21% to 85% increase in incident asthma (strongest effect from prenatal maternal smoking on asthma in children aged #2 years, OR = 1.85, 95% CI = 1.35-2.53, 5 studies).CONCLUSIONS: Building upon previous findings, exposure to passive smoking increases the incidence of wheeze and asthma in children and young people by at least 20%. Preventing parental smoking is crucially important to the prevention of asthma. Pediatrics 2012;129:735-744 AUTHORS:

show abstract

Wheeze associated with prenatal tobacco smoke exposure: a prospective, longitudinal study

Cited by 103 publications

References 18 publications

Indoor and Outdoor Environmental Exposures, Parental Atopy, and Physician-Diagnosed Asthma in Taiwanese Schoolchildren

Indoor and Outdoor Environmental Exposures, Parental Atopy, and Physician-Diagnosed Asthma in Taiwanese Schoolchildren

Pre- and postnatal parental smoking and wheeze in infancy: cross cultural differences

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

Contact Info

Product

Resources

About