Wheatgrass inhibits the lipopolysaccharide-stimulated inflammatory effect in RAW 264.7 macrophages

Abstract

Graphical abstract

Wheatgrass extract imparts neuroprotective actions against scopolamine-induced amnesia in mice

“…The W5 extract contained a marginally higher quantity of phenolic acids and flavonoids compared to the W7 extract. 19 Table 3 lists the major polyphenolic components and their concentrations in wheatgrass on days 5 and 7.…”

“…20 It has been reported previously in our in vitro study that wheatgrass decreases the production of free radicals and inflammatory proteins in inflammatory macrophage cells. 19 In another epidemiological study, it was reported that a specific dose of wheatgrass extract can reduce oxidative stress and inflammation. 20,29 It has been previously reported that in the hippocampus of the amnesic mouse model the neurons are degenerated thus resulting in neurobehavioral changes.…”

“…17 Wheatgrass has not been shown to cross the blood-brain barrier directly, but its high antioxidant potential may provide neuroprotection against oxidative damage and inflammation. 18,19 Antioxidant properties were discovered in vivo at concentrations ranging from 10 to 200 mg per kg bw. 20 Wheatgrass has been shown in recent studies to prevent the progression of the inflammatory state by activating anti-inflammatory cytokines (IL-10) and inhibiting the expression of inflammatory markers (IL-6, IL-1β, and NF-κB).…”

Protective Effect of Wheat and Barley Grass Against the Acute Toxicological Effects of the Concurrent Administration of Excessive Heavy Metals in Drinking Water on the Rats Liver and Brain

“…It contains several antioxidant vitamins such as A, B, C and E; antioxidant content chlorophyll; and antioxidant enzymes such as SOD, cytochrome oxidase, and other enzymes. Banerjee et al [58] reported that wheatgrass is a plentiful source of numerous flavonoids, mainly apigenin, with anti-oxidant and anti-carcinogenic potentials.…”

“…In addition, the stimulated lipid peroxidation was assessed by a significant elevation in the lipid peroxidation by-products of malondialdehyde (MDA) and NO. Banerjee et al [58] stated that NO is an essential chemical compound that plays a significant role in many inflammation stages. The increase in NO production results in the onset and development of many unhealthy conditions like cancer, type one diabetes, psoriasis, sepsis, colitis, arthritis, and multiple sclerosis.…”