2023
DOI: 10.1007/s10068-023-01289-y
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Wheat sprouts (Triticum aestivum Linn.) cultured by a smart farm system ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway

Abstract: Wheat is cultivated worldwide and is the most widely distributed food crop. Wheat is a staple crop in many countries. However, the effects of various cultivation methods on the efficacy of wheat sprouts have not been determined. This study investigated wheat sprouts obtained using a standardized smart farm system (WS-S) to improve the effects of non-alcoholic fatty liver disease (NAFLD) and molecular mechanism. Wheat sprouts significantly attenuated the accumulation of lipid droplets in FFA-induced HepG2 cells… Show more

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Cited by 2 publications
(1 citation statement)
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“…In this sense, the elevation of high-density lipoprotein as a result of feeding hydroponic wheat sprouts here would avoid the accumulation of cholesterol in peripheral tissues impacting positively on ewes’ health and welfare. Chang et al [ 17 ] elucidated that wheat sprouts could significantly attenuate the accumulation of lipid droplets in liver cells and non-alcoholic fatty liver disease-induced mice through the AMPK pathway activity, accompanied by the decrease of total cholesterol in the blood. Another study indicated that the extraction of wheat sprouts could suppress acetaminophen-induced hepatotoxicity in mice, manifested by inhibiting oxidative liver damage and reducing the expression of inflammatory cytokines [ 18 ].…”
Section: Discussionmentioning
confidence: 99%
“…In this sense, the elevation of high-density lipoprotein as a result of feeding hydroponic wheat sprouts here would avoid the accumulation of cholesterol in peripheral tissues impacting positively on ewes’ health and welfare. Chang et al [ 17 ] elucidated that wheat sprouts could significantly attenuate the accumulation of lipid droplets in liver cells and non-alcoholic fatty liver disease-induced mice through the AMPK pathway activity, accompanied by the decrease of total cholesterol in the blood. Another study indicated that the extraction of wheat sprouts could suppress acetaminophen-induced hepatotoxicity in mice, manifested by inhibiting oxidative liver damage and reducing the expression of inflammatory cytokines [ 18 ].…”
Section: Discussionmentioning
confidence: 99%