Post the 2015-2016 student movement calling for higher education transformation and decolonisation, institutions of higher learning in South Africa have continued to grapple with how to respond to these ethical and imperative demands. These challenges include the need to decolonise and Africanise curricula; diversity; foregrounding knowledge as an object of study. Further, responding to what Keet (2014) terms as the 'plastic knowledges' in the transformations and stagnations in the Humanities; challenging and deconstructing alienating institutional culture(s)particularly in historically white higher education institutions; the often forgotten and marginalised experiences of queer, transgendered, students and staff. One of the disciplines that has come under intensive scrutiny has been Political Science, being accused of being 'irrelevant' and teaching 'dead white men' with no epistemic connection to our local context. In this article, I attempt to respond to the above-mentioned critiques. I rely on Gramsci's notion of the organic crisis and Quijano's epistemic disobedience to bring them together in firstly, making sense of the nature of the crisis in South African higher education curriculum in general and Political Science in particular. And secondly, as both theoretical and empirical tools of de-linking the Political Science curriculum from coloniality and making curricula more transformative, socially just and inclusive. I argue that for Political Science to reclaim its relevance in an increasingly transdisciplinary world, it is necessary for us to not only know and understand the disciplinary crisis that confronts the discipline, but it is also necessary for us to begin to propose some of the epistemic solutions that can Mlamuli Nkosingphile Hlatshwayo 66 respond to the crisis that Political Science is facing. I employ epistemic disobedience to reclaim and re-centre African Philosophy, in particular, ethnophilosophy and nationalist-ideological philosophyas an attempt at making Political Science relevant to both the African experience(s) and to the broader global community.