What we have learned about lymphocytic variant hypereosinophilic syndrome: A systematic literature review

Shi, Yiyun; Wang, Chen

doi:10.1016/j.clim.2022.108982

Cited by 12 publications

(14 citation statements)

References 83 publications

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“…Importantly, detection of an isolated clonal TCR rearrangement in the absence of an abnormal T cell phenotype is not sufficient for diagnosis of L‐HES even if clinical criteria of HES are fulfilled 15,54,55 . Patients with L‐HES are at increased risk for the development of a lymphoproliferative disease and should be followed accordingly 58–60 …”

Section: Reactive He (Her)mentioning

confidence: 99%

“…The classification divides HES into familial/inherited HES (HES FA ), idiopathic HES (HES I ), reactive HES (HES R ), and clonal/neoplastic HES (HES N ) (Table 3). As mentioned before, the lymphoid variant of HES (L‐HES) is considered a reactive form of HES in which eosinophils are non‐clonal cells triggered by T cell‐derived cytokines 54–60 . The diagnosis HES FA is established when HE FA is identified and the clinical criteria of HES (typical organ damage) are fulfilled 15,23 …”

Section: Definition Criteria and Classification Of Hesmentioning

confidence: 99%

“…15,54,55 Patients with L-HES are at increased risk for the development of a lymphoproliferative disease and should be followed accordingly. [58][59][60] In a subset of (mostly pediatric) patients with B cell acute lymphoblastic leukemia, a specific translocation, t(5;14)(q31;q32), leads to juxtaposition of the IgH enhancer and the IL-3 gene, resulting in (over)production of IL-3 by leukemic cells; these patients may also present with (reactive) HE.…”

Section: Re Ac Tive He (He R )mentioning

confidence: 99%

“…As mentioned before, the lymphoid variant of HES (L-HES) is considered a reactive form of HES in which eosinophils are non-clonal cells triggered by T cell-derived cytokines. [54][55][56][57][58][59][60] The diagnosis HES FA is established when HE FA is identified and the clinical criteria of HES (typical organ damage) are fulfilled. 15,23 An important point is that HES should be differentiated from clinical syndromes associated with HE but that do not meet criteria for HES, such as some of the inborn errors of immunity and organrestricted inflammatory conditions where HE is present but does not play a major role in organ damage or dysfunction, and typical symptoms of HES are uncommon (Tables S3, S7 and S8).…”

Section: Hematologicmentioning

confidence: 99%

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Proposed refined diagnostic criteria and classification of eosinophil disorders and related syndromes

Valent

Klion

Roufosse

et al. 2022

Allergy

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Eosinophilia and eosinophil activation are recurrent features in various reactive states and certain hematologic malignancies. In patients with hypereosinophilia (HE), HE-induced organ damage is often encountered and may lead to the diagnosis of a hypereosinophilic syndrome (HES). A number of known mechanisms and etiologies contribute to the development of HE and HES. Based on these etiologies and the origin of eosinophils, HE and HES are divided into primary forms where eosinophils are clonal cells, reactive forms where an underlying reactive or neoplastic condition is detected and eosinophils are considered to be "non-clonal" cells, and idiopathic HE and HES in which neither a clonal nor a reactive underlying pathology is detected.Since 2012, this classification and the related criteria have been widely accepted and regarded as standard. However, during the past few years, new developments in the field and an increasing number of markers and targets have created a need to update these criteria and the classification of HE and HES. To address this challenge, a Working Conference on eosinophil disorders was organized in 2021. In this conference, a panel of experts representing the relevant fields, including allergy, dermatology, hematology, immunology, laboratory medicine, and pathology, met and discussed new markers and concepts as well as refinements in definitions, criteria and classifications of HE and HES. The outcomes of this conference are presented in this article and should assist in the diagnosis and management of patients with HE and HES in daily practice and in the preparation and conduct of clinical trials.

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Section: Reactive He (Her)mentioning

confidence: 99%

Section: Definition Criteria and Classification Of Hesmentioning

confidence: 99%

Section: Re Ac Tive He (He R )mentioning

confidence: 99%

Section: Hematologicmentioning

confidence: 99%

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Proposed refined diagnostic criteria and classification of eosinophil disorders and related syndromes

Valent

Klion

Roufosse

et al. 2022

Allergy

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“…Although primary nodal PTCL has been described during the course of lymphoid HES, 4 to our knowledge, primary CTCL has not been reported so far. Lymphoid HES and Sézary syndrome share a common gene expression pattern and elevated serum levels of TARC (thymus and activation‐regulated chemokine), 4 a CCR4 ligand, further supporting a common pathophysiology. Indeed, CCR4 is expressed by both CTCL tumour cells and CD3 − CD4 + T‐cell clones in lymphoid HES 7 .…”

Section: Figurementioning

confidence: 81%