What was old is new again: using the host response to diagnose infectious disease

Ko, Emily R; Yang, William; McClain, Micah T.; Woods, Christopher W.; Ginsburg, Geoffrey S.; Tsalik, Ephraim L.

doi:10.1586/14737159.2015.1059278

Cited by 28 publications

(28 citation statements)

References 171 publications

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“…Over the past several years numerous transcriptomic studies have looked at sepsis diagnosis as well as patient outcomes (review in [65]). Unfortunately, these biomarker studies have performed poorly as numerous pathways and signatures were implicated, but rarely validated independently.…”

Section: Transcriptomic Analysis Of the Host Response To Diagnose Infmentioning

confidence: 99%

Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?

Wong

2017

Mol Diagn Ther

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Sepsis remains one of the leading causes of death in the United States and it is expected to get worse as the population ages. Moreover, the standard of care, which recommends aggressive treatment with appropriate antibiotics, has led to an increase in multiple drug resistant organisms (MDROs). There is a dire need for the development of new antibiotics, improved antibiotic stewardship and therapies that treat the host response. Development of new sepsis therapeutics has been a disappointment as no drugs are currently approved to treat the various complications from sepsis. Much of the failure has been blamed on animal models that do not accurately reflect the course of the disease. However, recent improvements in metabolomic, transcriptomic, genomic and proteomic platforms have allowed for a broad spectrum look at molecular changes in the host response using clinical samples. Integration of these multi-omic data sets allows researchers to perform systems biology approaches to identify novel pathophysiology of the disease. In this review, we will highlight what is currently known about sepsis and how integrative omics has identified new diagnostic and predictive models of sepsis as well as novel mechanisms. These changes may improve patient care as well as guide future preclinical analysis of sepsis.

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Section: Transcriptomic Analysis Of the Host Response To Diagnose Infmentioning

confidence: 99%

Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?

Wong

2017

Mol Diagn Ther

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“…Aspergillus infection can leave traces in the host by the release of Aspergillus ‐specific metabolites or mixtures of metabolites . Alternatively, infections can initiate changes to the host's metabolome, which can be detected . In both instances, cutting‐edge analytical methods have been developed to detect the “signature” of pathogen infection.…”

Section: Metabolicmentioning

confidence: 99%

“…Like proteomics, metabolomics is another ‐omics technology that detects all metabolites in biological samples, and can identify metabolites or mixtures unique to infecting pathogens or detect changes in infected host metabolic profiles that can be adapted to infectious disease diagnostics . The most common metabolomic detection methods are nuclear magnetic resonance (NMR) and MS .…”

Section: Metabolicmentioning

confidence: 99%

The current status of avian aspergillosis diagnoses: Veterinary practice to novel research avenues

Savelieff¹,

Pappalardo

Azmanis

2018

Veterinary Clinical Pathol

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Aspergillus fungal infections continue to be a significant cause of morbidity and mortality in birds that can, in part, be attributed to the lack of a diagnostic "gold standard" for Aspergillus infection, and which delays the diagnosis, treatment, and outcome of avian patients. At present, none of the available methods in veterinary care can detect aspergillosis early enough and with the accuracy, precision, and specificity required of an ideal diagnostic tool. Therefore, researching methods of Aspergillus detection is still an active area of inquiry, and novel techniques continue to emerge. This review will provide a brief overview of current clinical methods, with an emphasis on avian care, in addition to a series of techniques in development that could offer distinct advantages over existing methods.

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“…Recently, investigators have embarked on exploratory approaches, taking advantage of advanced “omics” technologies to more deeply understand serious bacterial infection in infants, children, and adults (34–36, 47). Omics denotes the comprehensive investigation of any family of biologic molecules, including DNA (genomics), RNA transcripts (transcriptomics), proteins (proteomics), and metabolites (metabolomics), among others.…”

Section: Omics To Extend Knowledge Of Bacterial Meningitismentioning

confidence: 99%

Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics

2017

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Neonatal meningitis is a devastating condition. Prognosis has not improved in decades, despite the advent of improved antimicrobial therapy and heightened index of suspicion among clinicians caring for affected infants. One in ten infants die from meningitis, and up to half of survivors develop significant lifelong complications, including seizures, impaired hearing and vision, and delayed or arrested development of such basic skills as talking and walking. At present, it is not possible to predict which infants will suffer poor outcomes. Early treatment is critical to promote more favorable outcomes, though diagnosis of meningitis in infants is technically challenging, time-intensive, and invasive. Profound neuronal injury has long been described in the setting of neonatal meningitis, as has elevated levels of many pro- and anti-inflammatory cytokines. Mechanisms of the host immune response that drive clearance of the offending organism and underlie brain injury due to meningitis are not well understood, however. In this review, we will discuss challenges in diagnosis, prognosis, and treatment of neonatal meningitis. We will highlight transcriptomic, proteomic, and metabolomic data that contribute to suggested mechanisms of inflammation and brain injury in this setting with a view toward fruitful areas for future investigation.

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What was old is new again: using the host response to diagnose infectious disease

Cited by 28 publications

References 171 publications

Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?

Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?

The current status of avian aspergillosis diagnoses: Veterinary practice to novel research avenues

Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics

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