What to advise to patients with only one good quality blastocyst, PGT-A or not? Outcomes of 2064 cycles

Abstract

Purpose To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) is beneficial for patients who have only one blastocyst available for biopsy or transfer. Methods This retrospective study was based on 1126 single blastocyst PGT-A and 938 non-PGT-A cycles, a total of 2064 ART cycles which resulted in a single good quality blastocyst in women between 20 and 45 years old. The PGT-A group had 225 single euploid embryo transfer cycles and the non-PGT-A group had 938 single blastocyst embryo transfer cycles. Results In the generalized linear mixed model (GLMM), female age and PGT-A variables were found to be significant variables on pregnancy outcomes. In the PGT-A cases, regardless of the effect of other variables, the probabilities of clinical pregnancy and live birth were found to be 3.907 and 3.448 fold higher respectively than in the non-PGT-A cases (p < 0.001). In non PGT-A cases, the probability of a total pregnancy loss was found to be 1.943 fold higher (p = 0.013). Conclusion PGT-A in the presence of a single blastocyst significantly increases clinical pregnancy and live birth rates and decreases total pregnancy losses regardless of age. In addition, aneuploid embryo transfer cancelations prevent ineffective and potentially risky transfers.

The probability of detriment as well as benefit needs to be presented for PGT-A

“…The recent article by Kahraman and colleagues [1] reports the results of a study concerning the utility of preimplantation genetic testing for aneuploidy (PGT-A) for couples of poor prognosis who had only 1 blastocyst available. Their study demonstrated that PGT-A had efficacy to distinguish viable and non-viable embryos with various benefits.…”

What to advise to patients with only one good quality blastocyst, PGT-A or not? Outcomes of 2064 cycles

“…To the Editor, We perceive a need to comment on the study by Kahraman et al, [1] who retrospectively compared the IVF outcomes of patients who had only a single good-quality blastocyst and underwent transfer either with (n = 1126) or without preimplantation genetic testing for aneuploidy (PGT-A) (n = 938). The PGT-A group had 225 and the non-PGT-A group had 938 single euploid embryo transfer cycles.…”