What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons

Cole, Anthony B.; Montgomery, Kristen; Bale, Tracy L.; Thompson, Scott M.

doi:10.1016/j.ynstr.2022.100473

Cited by 23 publications

(15 citation statements)

References 94 publications

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“…The hippocampus is known to encode contextual information, is necessary for the acquisition and retrieval of extinction of fear-associated memories ( Maren and Holt, 2000 ; Bissiere et al, 2011 ), and coordinates information processing and filtering in the limbic network ( Çalışkan and Stork, 2019 ). While the role of the FCx in stress response is complex, since different anatomic subdivisions play different roles ( Sullivan and Gratton, 2002 ; Radley et al, 2006 ), it influences emotional, social, and goal-directed behaviors ( Cole et al, 2022 ). In our previous study, using the same dataset of stress-induced anxiety-like behavior ( Laine et al, 2018 ), we found high overlap in differential gene expression of C57BL/6NCrl and DBA/2NCrl susceptible mice after CSDS in the ventral hippocampus but not in the medial prefrontal cortex.…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, the hippocampal gene expression patterns were similar between both C57BL/6NCrl and DBA/2NCrl susceptible mice and mice with innate anxiety-like behavior. The Hpc is known to exert both synaptic and neuroendocrine inhibitory feedback on the hypothalamic-pituitary-adrenal (HPA) axis and is a key brain region for the modulation of anxiety ( Jacobson and Sapolsky, 1991 ; Cole et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

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Gene expression profiling reveals a role of immune system and inflammation in innate and stress-induced anxiety-like behavior

et al. 2023

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Anxiety is an evolutionarily conserved response that is essential for survival. Pathological anxiety, however, is a maladaptive response to nonthreatening situations and greatly affects quality of life. The recent COVID-19 pandemic has increased the prevalence of anxiety symptoms and highlighted the urge to identify the molecular events that initiate pathological anxiety. To this aim, we investigated the extent of similarity of brain region-specific gene expression patterns associated with innate and stress-induced anxiety-like behavior. We compared the cortico-frontal (FCx) and hippocampal (Hpc) gene expression patterns of five inbred mouse strains with high or low levels of innate anxiety-like behavior with gene expression patterns of mice subjected to chronic social defeat stress. We found significantly large overlap of the Hpc but small overlap of the FCx gene expression patterns in innate and stress-induced anxiety, that however, converged onto common inflammation and immune system canonical pathways. Comparing the gene expression data with drug-gene interaction datasets revealed drug candidates, including medrysone, simvastatin, captopril, and sulpiride, that produced gene expression changes opposite to those observed in innate or stress-induced anxiety-like behavior. Together, our data provide a comprehensive overview of FCx and Hpc gene expression differences between innate and stress-induced anxiety and support the role of inflammation and immune system in anxiety-like behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gene expression profiling reveals a role of immune system and inflammation in innate and stress-induced anxiety-like behavior

et al. 2023

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“…Corticosterone levels were determined using a corticosterone double antibody radioimmunoassay (RIA, MP Biomedicals), according to the kit instructions and as previously described 83 , 84 . Briefly, plasma was diluted 1:200 using the steroid diluent included in the kit.…”

Section: Methodsmentioning

confidence: 99%

Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy

Zierden

Marx-Rattner

Rock

et al. 2023

Sci Rep

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Homeostatic regulation of the maternal milieu during pregnancy is critical for maternal and fetal health. The placenta facilitates critical communication between maternal and fetal compartments, in part, through the production of extracellular vesicles (EVs). EVs enable tissue synchrony via cell–cell and long-distance communication and are at their highest circulating concentration during pregnancy. While much work has been done investigating how physiological challenges in pregnancy affect the fetus, the role of placental communication in maternal health has not been well examined. We previously identified placental O-glycosyl transferase (OGT), a glucose-sensing enzyme, as a target of maternal stress where OGT levels and activity affected the O-glycosylation of proteins critical for EV cargo loading and secretion. Here, we hypothesized that placental OGT plays an essential role in maternal homeostatic regulation during pregnancy via its regulation of maternal circulating EV concentrations. Our studies found that changes to key metabolic factors over the circadian cycle, including glucocorticoids, insulin, and glucose, were significantly associated with changes in circulating EV concentration. Targeting placental OGT in mice, we found a novel significant positive relationship between placental OGT and maternal circulating EV concentration that was associated with improving maternal glucose tolerance during pregnancy. Finally, an intravenous elevation in EVs, matching the concentration of EVs during pregnancy, shifted non-pregnant female glucose sensitivity, blunted glucose variance, and improved synchrony of glucose uptake. These data suggest an important and novel role for circulating EVs as homeostatic regulators important in maternal health during pregnancy.

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“…An important role belongs to the structures of the limbic system (hippocampus, medial prefrontal cortex, and amygdala) [ 151 ]. The hippocampus regulates the HPAA by inhibiting its activity [ 152 , 153 , 154 , 155 ]. HPAA activity is also regulated by the medial prefrontal cortex.…”

Section: The Neuroendocrine Hypothesis Of Depression and Melanocortinsmentioning

confidence: 99%

The Melanocortin System: A Promising Target for the Development of New Antidepressant Drugs

Markov

Долотов

Гривенников

2023

IJMS

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Major depression is one of the most prevalent mental disorders, causing significant human suffering and socioeconomic loss. Since conventional antidepressants are not sufficiently effective, there is an urgent need to develop new antidepressant medications. Despite marked advances in the neurobiology of depression, the etiology and pathophysiology of this disease remain poorly understood. Classical and newer hypotheses of depression suggest that an imbalance of brain monoamines, dysregulation of the hypothalamic-pituitary-adrenal axis (HPAA) and immune system, or impaired hippocampal neurogenesis and neurotrophic factors pathways are cause of depression. It is assumed that conventional antidepressants improve these closely related disturbances. The purpose of this review was to discuss the possibility of affecting these disturbances by targeting the melanocortin system, which includes adrenocorticotropic hormone-activated receptors and their peptide ligands (melanocortins). The melanocortin system is involved in the regulation of various processes in the brain and periphery. Melanocortins, including peripherally administered non-corticotropic agonists, regulate HPAA activity, exhibit anti-inflammatory effects, stimulate the levels of neurotrophic factors, and enhance hippocampal neurogenesis and neurotransmission. Therefore, endogenous melanocortins and their analogs are able to complexly affect the functioning of those body’s systems that are closely related to depression and the effects of antidepressants, thereby demonstrating a promising antidepressant potential.

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What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons

Cited by 23 publications

References 94 publications

Gene expression profiling reveals a role of immune system and inflammation in innate and stress-induced anxiety-like behavior

Gene expression profiling reveals a role of immune system and inflammation in innate and stress-induced anxiety-like behavior

Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy

The Melanocortin System: A Promising Target for the Development of New Antidepressant Drugs

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