What Should we Tell Patients About Hormones after Having Melanoma?

Johnston, Stephen

doi:10.1002/9780470987346.ch21

Cited by 2 publications

(1 citation statement)

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“…Surgery is a definitive therapy for early-stage disease (stage I and II melanoma), and this does not differ between pregnant and nonpregnant women, whereas the treatment of pregnant women with stage III and IV melanoma is less clear and more difficult. The use of chemotherapy during pregnancy is still an issue for discussion among oncologists, while there is insufficient evidence to warrant the use of adjuvant chemotherapy or biologic therapy during pregnancy (14)(15)(16). In addition to that, radiological examinations and the possible use of sentinel lymph node biopsies are considerations that modify management options for pregnant women.…”

Section: Commentsmentioning

confidence: 99%

Metastatic amelanotic nodular melanoma during pregnancy

Jasaitienė¹,

Valiukevičienė²,

Makštienė³

et al. 2008

Medicina

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This case report presents a very aggressive course of amelanotic nodular melanoma during pregnancy resulting in death five months after delivery. A 34 year-old Caucasian woman at 19th week of the second pregnancy was diagnosed having amelanotic nodular melanoma (tumor thickness – 2.5 mm) with metastases to the regional right inguinal lymph node. Amelanotic nodular melanoma represents malignant melanocytic tumor of the skin, which clinically mimics a variety of benign and malignant skin conditions and therefore commonly leads to delayed diagnosis. Though primary tumor was excised immediately, other treatment procedures as radical lymphadenectomy and chemotherapy were delayed, and immunotherapy was not given totally. At the 29th week of pregnancy, the woman via naturalem delivered a healthy female child, and the chemotherapy was started. Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our reported case. Such patients seems to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.

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Section: Commentsmentioning

confidence: 99%