What Should we do About Microalbuminuria?

Thomas, Stephen

doi:10.1002/9780470757109.ch4

Difficult Diabetes 2001

DOI: 10.1002/9780470757109.ch4

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What Should we do About Microalbuminuria?

Stephen Thomas¹

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2002

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The reno-protective role of AT1-receptor blockers

2002

J Hum Hypertens

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In the 1970s and 1980s it became evident that progression of renal disease and blood pressure are correlated. Subsequently, it was shown that antihypertensive treatment, especially with agents that block the renin-angiotensin system (RAS), could slow the progression of diabetic renal disease. Several studies, particularly with RAS blockers, have confirmed beneficial effects on urinary albumin excretion in patients with diabetes and microalbuminuria or proteinuria. There are good reasons to explore dual blockade of the RAS with an AT 1 -receptor blocker and an ACE inhibitor. Receptor blockers may block the effects of angiotensin II more effectively than ACE inhibitors; moreover, ACE inhibitors increase bradykinins which may have positive effects on blood pressure and renal function. Such combination treatment has been found to be well tolerated and more effective in reducing blood pressure than either

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The reno-protective role of AT1-receptor blockers

2002

J Hum Hypertens

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What Should we do About Microalbuminuria?

Cited by 1 publication

References 69 publications

The reno-protective role of AT1-receptor blockers

The reno-protective role of AT1-receptor blockers

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