What should be the characteristics of the ideal bone graft substitute?

Giannoudis, Peter V.; Arts, Jacobus J.; Schmidmaier, G.; Larsson, Sune

doi:10.1016/j.injury.2011.06.001

Cited by 43 publications

(68 citation statements)

References 19 publications

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“…[11][12][13] In addition, the ideal synthetic bone gra substitute should possess excellent mechanical properties to allow surgical handling and xation. 11,14 To achieve these goals, it is important to develop bone gra substitutes mimicking the chemical composition and structure of human natural bone. The natural bone is an inorganic-organic biocomposite with $70 wt% minerals mainly hydroxyapatite (HAP, Ca 10 (PO 4 ) 6 (OH) 2 ) and $30 wt% organic matrix (mainly type I collagen).…”

Section: -10mentioning

confidence: 99%

Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

Sun

Chen

2018

RSC Adv.

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The synthetic bone grafts that mimic the composition and structure of human natural bone exhibit great potential for application in bone defect repair. In this study, a biomimetic porous nanocomposite consisting of ultralong hydroxyapatite nanowires (UHANWs) and collagen (Col) with 66.7 wt% UHANWs has been prepared by the freeze drying process and subsequent chemical crosslinking. Compared with the pure collagen as a control sample, the biomimetic UHANWs/Col porous nanocomposite exhibits significantly improved mechanical properties. More significantly, the rehydrated UHANWs/Col nanocomposite exhibits an excellent elastic behavior. Moreover, the biomimetic UHANWs/Col porous nanocomposite has a good degradable performance with a sustained release of Ca and P elements, and can promote the adhesion and spreading of mesenchymal stem cells. The in vivo evaluation reveals that the biomimetic UHANWs/Col porous nanocomposite can significantly enhance bone regeneration compared with the pure collagen sample. After 12 weeks implantation, the woven bone and lamellar bone are formed throughout the entire UHANWs/Col porous nanocomposite, and connect directly with the host bone to construct a relatively normal bone marrow cavity, leading to successful osteointegration and bone reconstruction. The as-prepared biomimetic UHANWs/Col porous nanocomposite is promising for applications in various fields such as bone defect repair.

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Section: -10mentioning

confidence: 99%

Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

Sun

Chen

2018

RSC Adv.

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“…The treatment requires the correction of the fixation associated with a biological stimulation obtained with pulsed electromagnetic fields (PEMF), extracorporeal shock wave therapy (ESWT) or biotechnologies, such as mesenchymal stromal cells, growth factors or scaffold, in monorail therapy [18][19][20][21][22][23][24][25][26][27][28][29][30]. Score from 51 to 75 requires specialised care and specific treatments.…”

Section: Classificationmentioning

confidence: 99%

Validation of the Non-Union Scoring System in 300 long bone non-unions

Calori

Colombo

Mazza

et al. 2014

Injury

110

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“…The criteria for a good scaffold can be summarized under the 4 F's: form, function, fixation and formation. The currently available material only fulfills these criteria partially (56).…”

Section: Surgery According To the Diamond Conceptmentioning

confidence: 99%

Non-Union Current Treatment Concept

2016

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Context: This article wants to give a current concept for the challenging decision for conservative or operative treatment strategies of nonunions according to the principles of 'diamond concept' and aspects that have to be attended. Evidence Acquisition: Between February 2010 and March 2014, 424 patients with non-unions were treated at Heidelberg university hospital. This database has been analyzed at least one year after the treatment. The analysis and the experience in surgery and treatment of non-unions as well as present literature were prepared for this review as a current concept. Results: If an atrophic non-union is suggested, reosteosynthesis and biological stimulation is required. A revision surgery of autologous transplantation of cancellous bone from the iliac crest is often enough. Alternatively, reamer-irrigator-aspirator (RIA) can be taken out of the femur with lower complications and pain in the extraction area and be combined with growth factors like bone morphogenetic proteins (BMPs), if consolidation after cancellous bone is still absent. In complex cases, consequential and radical removal of the infection often improved circulation through interventional angiography and use of the two-step procedure (the Masquelet technique) as well as a tissue covering are required. Conclusions: By using the 'diamond concept' as a complex concept, non-unions can be treated in different stages in a targeted manner.

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What should be the characteristics of the ideal bone graft substitute?

Cited by 43 publications

References 19 publications

Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

Validation of the Non-Union Scoring System in 300 long bone non-unions

Non-Union Current Treatment Concept

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