What’s New in Pregnancy Tests

Brucker, Mary C.; MacMullen, Nancy J.

doi:10.1111/j.1552-6909.1985.tb02082.x

Cited by 14 publications

(9 citation statements)

References 2 publications

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“…13 In the time between a woman's last period and any pregnancy test result, it is impossible to know with certainty whether she is in fact pregnant. Significantly, this time span of 'unknown condition' is almost identical to the period of time recommended for the early use of RU486/PG.…”

Section: Lawsmentioning

confidence: 99%

The search for meaning: RU486/PG, pregnancy and the law of abortion

Banwell¹,

Paxman²

1993

Reproductive Health Matters

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Section: Lawsmentioning

confidence: 99%

The search for meaning: RU486/PG, pregnancy and the law of abortion

Banwell¹,

Paxman²

1993

Reproductive Health Matters

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“…The prototype design of LFA was first reported in 1956 by Plotz and Singer 6 , which later gained explosive attention from the 1980s when the urine-based pregnancy test became commercially available 7 . Indeed, as a type of disposable paper assay with a user-friendly format, LFA fulfils the framework of ASSURED (affordable, sensitive, specific, user-friendly, robust, equipment-free and deliverable) for POCT evaluation proposed by the World Health Organization 8 .…”

Section: Introductionmentioning

confidence: 99%

Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis

et al. 2021

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Lateral flow assay (LFA) has made a paradigm shift in the in vitro diagnosis field due to its rapid turnaround time, ease of operation and exceptional affordability. Currently used LFAs predominantly use antibodies. However, the high inter-batch variations, error margin and storage requirements of the conventional antibody-based LFAs significantly impede its applications. The recent progress in aptamer technology provides an opportunity to combine the potential of aptamer and LFA towards building a promising platform for highly efficient point-of-care device development. Over the past decades, different forms of aptamer-based LFAs have been introduced for broad applications ranging from disease diagnosis, agricultural industry to environmental sciences, especially for the detection of antibody-inaccessible small molecules such as toxins and heavy metals. But commercial aptamer-based LFAs are still not used widely compared with antibodies. In this work, by analysing the key issues of aptamer-based LFA design, including immobilization strategies, signalling methods, and target capturing approaches, we provide a comprehensive overview about aptamer-based LFA design strategies to facilitate researchers to develop optimised aptamer-based LFAs.

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“…Previously, we developed a rapid diagnosis kit according to the principle of immunochromatography to study cobra bites [21]. The kit used a lateral flow assay (LFA) with an immunochromato-microfluidic paper-based device that has been widely used to detect pregnancy, drugs, bacteria, viruses, and cardiac biomarker as the technique has advanced [22][23][24][25][26][27]. Based on this LFA method, we could differentiate cobra snake bites from other viper bites quickly in the same area [21].…”

Section: Introductionmentioning

confidence: 99%

Collocation of avian and mammal antibodies to develop a rapid and sensitive diagnostic tool for Russell's Vipers Snakebite

Lin

Chuang

et al. 2020

PLoS Negl Trop Dis

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Russell's vipers (RVs) envenoming is an important public health issue in SouthEast Asia. Disseminated intravascular coagulopathy, systemic bleeding, hemolysis, and acute renal injury are obvious problems that develop in most cases, and neuromuscular junction blocks are an additional problem caused by western RV snakebite. The complex presentations usually are an obstacle to early diagnosis and antivenom administration. Here, we tried to produce highly specific antibodies in goose yolks for use in a paper-based microfluidic diagnostic kit, immunochromatographic test of viper (ICT-Viper), to distinguish RVs from other vipers and even cobra snakebite in Asia. We used indirect ELISA to monitor specific goose IgY production and western blotting to illustrate the interaction of avian or mammal antibody with venom proteins. The ICT-Viper was tested not only in prepared samples but also in stored patient serum to demonstrate its preliminary efficacy. The results revealed that specific anti-Daboia russelii IgY could be raised in goose eggs effectively without inducing adverse effects. When it was collocated with horse anti-Daboia siamensis antibody, which broadly reacted with most of the venom proteins of both types of Russell's viper, the false cross-reactivity was reduced, and the test showed good performance. The limit of detection was reduced to 10 ng/ml in vitro, and the test showed good detection ability in clinical snake envenoming case samples. The ICT-Viper performed well and could be combined with a cobra venom detection kit (ICT-Cobra) to create a multiple detection strip (ICT-VC), which broadens its applications while maintaining its detection ability for snake envenomation identification. Nonetheless, the use of the ICT-Viper in the SouthEast Asia region is pending additional laboratory and field investigations and regional collaboration. We believe that the development of this practical diagnostic tool marks the beginning of positive efforts to face the global snakebite issue.

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What’s New in Pregnancy Tests

Cited by 14 publications

References 2 publications

The search for meaning: RU486/PG, pregnancy and the law of abortion

The search for meaning: RU486/PG, pregnancy and the law of abortion

Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis

Collocation of avian and mammal antibodies to develop a rapid and sensitive diagnostic tool for Russell's Vipers Snakebite

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