What’s New in Limb Lengthening and Deformity Correction

Bafor, Anirejuoritse; Iobst, Christopher

doi:10.2106/jbjs.23.00310

Cited by 1 publication

(1 citation statement)

References 74 publications

(79 reference statements)

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“…[ 7 ] However, despite continuous refinements in the Ilizarov technique within clinical practices of orthopedic and plastic surgery, the slow mineralization rate of newly formed bone in the distraction zone remains a major challenge faced by both medical practitioners and patients. [ 8 ] To address this issue, one approach involves exploring physicochemical or biological auxiliary measures directly based on the DO model, which is currently the predominant approach adopted in most relevant studies. [ 9 ] Additionally, recognizing the unique biological characteristics of the DO model distinct from mere segmental bone defect (SBD) healing, and subsequently improving or transforming the Ilizarov technique, represents another highly promising strategy for limb lengthening and reconstruction research.…”

Section: Introductionmentioning

confidence: 99%

Tensile Stress‐Activated and Exosome‐Transferred YAP/TAZ‐Notch Circuit Specifies Type H Endothelial Cell for Segmental Bone Regeneration

Wang,

Li,

Kong

et al. 2024

Advanced Science

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The Ilizarov technique has been continuously innovated to utilize tensile stress (TS) for inducing a bone development‐like regenerative process, aiming to achieve skeletal elongation and reconstruction. However, it remains uncertain whether this distraction osteogenesis (DO) process induced by TS involves the pivotal coupling of angiogenesis and osteogenesis mediated by type H endothelial cells (THECs). In this study, it is demonstrated that the Ilizarov technique induces the formation of a metaphysis‐like architecture composed of THECs, leading to segmental bone regeneration during the DO process. Mechanistically, cell‐matrix interactions‐mediated activation of yes‐associated protein (YAP)/transcriptional co‐activator with PDZ‐binding motif (TAZ) transcriptionally upregulates the expression of Notch1 and Delta‐like ligand 4, which act as direct positive regulators of THECs phenotype, in bone marrow endothelial cells (BMECs) upon TS stimulation. Simultaneously, the Notch intracellular domain enhances YAP/TAZ activity by transcriptionally upregulating YAP expression and stabilizing TAZ protein, thus establishing the YAP/TAZ‐Notch circuit. Additionally, TS‐stimulated BMECs secrete exosomes enriched with vital molecules in this positive feedback pathway, which can be utilized to promote segmental bone defect healing, mimicking the therapeutic effects of Ilizarov technique. The findings advance the understanding of TS‐induced segmental bone regeneration and establish the foundation for innovative biological therapeutic strategies aimed at activating THECs.

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Section: Introductionmentioning

confidence: 99%