What's new about etiopathogenesis of musculoskeletal injuries in adolescent athletes?

Turati, Marco; Boerci, Linda; Piatti, Massimiliano; Zanchi, Nicolò; Zatti, Giovanni; Accadbled, Franck; Bigoni, Marco

doi:10.23736/s0026-4946.20.05944-7

Cited by 13 publications

(11 citation statements)

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“…All the studies considered investigated treatment strategies for acute ankle sprains. Six reviews investigated specifically acute treatment (18-23) (AMSTAR range [3][4][5][6][7][8][9][10][11]. Two reviews evaluated drug therapy (24, 25) (AMSTAR range [8][9][10][11].…”

Section: Study Selectionmentioning

confidence: 99%

“…Three reviews analyzed other treatments (35-37) (AMSTAR range 6-10). Finally, four reviews considered return to sport (38-41) (AMSTAR range [4][5][6][7][8][9][10][11]. Table 3 summarizes the results and conclusions of included studies, grouped based on the intervention type.…”

Section: Study Selectionmentioning

confidence: 99%

“…Epidemiological data have shown that ∼80% of individuals will suffer an ankle sprain during their lifetime (3,4). This injury is more frequent in women than in men; likewise, children are more affected than adolescents and adults: the progressive development of coordination patterns and neuromuscular control plays a protective role (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

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Acute Ankle Sprain Management: An Umbrella Review of Systematic Reviews

et al. 2022

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Even though ankle sprains are among the most frequent musculoskeletal injuries seen in emergency departments, management of these injuries continues to lack standardization. Our objective was to carry out an umbrella review of systematic reviews to collect the most effective evidence-based treatments and to point out the state-of-the-art management for this injury. PubMed, Scopus, Web of Science, and the Cochrane library were searched from January 2000 to September 2020. After removing duplicates and applying the eligibility criteria, based on titles and abstracts, 32 studies were screened. At the end of the process, 24 articles were included in this umbrella review with a mean score of 7.7/11 on the AMSTAR quality assessment tool. We found evidence supporting the effectiveness of non-surgical treatment in managing acute ankle sprain; moreover, functional treatment seems to be preferable to immobilization. We also found evidence supporting the use of paracetamol or opioids as effective alternatives to non-steroidal anti-inflammatory drugs to reduce pain. Furthermore, we found evidence supporting the effectiveness of manipulative and supervised exercise therapy to prevent re-injury and restore ankle dorsiflexion.

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Section: Study Selectionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acute Ankle Sprain Management: An Umbrella Review of Systematic Reviews

et al. 2022

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“…This miRNA is a positive modulator of cellular proliferation of the growth plate [ 18 ]. However, the real role of miRNA 140-5p in intraarticular pediatric knee lesions, such as ACL, meniscal, and chondral tears has not yet been defined [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of microRNA Levels in Synovial Fluid from Knee Osteoarthritis and Anterior Cruciate Ligament Tears

et al. 2022

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This study investigated modifications of microRNA expression profiles in knee synovial fluid of patients with osteoarthritis (OA) and rupture of the anterior cruciate ligament (ACL). Twelve microRNAs (26a-5p, 27a-3p, let7a-5p, 140-5p, 146-5p, 155-5p, 16-5p,186-5p, 199a-3p, 210-3p, 205-5p, and 30b-5p) were measured by real-time quantitative polymerase chain reaction (RT-qPCR) in synovial fluids obtained from 30 patients with ACL tear and 18 patients with knee OA. These 12 miRNAs were chosen on the basis of their involvement in pathological processes of bone and cartilage. Our results show that miR-26a-5p, miR-186-5p, and miR-30b-5p were expressed in the majority of OA and ACL tear samples, whereas miR-199a-3p, miR-210-3p, and miR-205-5p were detectable only in a few samples. Interestingly, miR-140-5p was expressed in only one sample of thirty in the ACL tear group. miR-140-5p has been proposed to modulate two genes (BGN and COL5A1100) that are involved in ligamentous homeostasis; their altered expression could be linked with ACL rupture susceptibility. The expression of miR-30b-5p was higher in OA and chronic ACL groups compared to acute ACL samples. We provide evidence that specific miRNAs could be detected not only in synovial fluid of patients with OA, but also in post-traumatic ACL tears.

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“…Despite advances in our understanding of this condition, many issues remain unresolved; particularly the pathophysiology, indications for magnetic resonance imaging (MRI), and MRI signs of instability. 2 …”

Section: Introductionmentioning

confidence: 99%

Osteochondritis dissecans of the knee: Imaging, instability concept, and criteria

Accadbled

Turati

Kocher

2023

Journal of Children's Orthopaedics

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Osteochondritis dissecans of the knee is an idiopathic, focal, subchondral-bone abnormality that can cause instability or detachment of a bone fragment and overlying articular cartilage, with subsequent progression to osteoarthritis. The degree of lesion instability is best assessed by magnetic resonance imaging. Unstable lesions require operative management with fragment fixation. Level of evidence: V.

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What's new about etiopathogenesis of musculoskeletal injuries in adolescent athletes?

Cited by 13 publications

References 0 publications

Acute Ankle Sprain Management: An Umbrella Review of Systematic Reviews

Acute Ankle Sprain Management: An Umbrella Review of Systematic Reviews

Characterization of microRNA Levels in Synovial Fluid from Knee Osteoarthritis and Anterior Cruciate Ligament Tears

Osteochondritis dissecans of the knee: Imaging, instability concept, and criteria

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