This paper describes salient aspects of the OntoSem lexicon of English, a lexicon whose semantic descriptions can either be grounded in a language-independent ontology, rely on extra-ontological expressive means, or exploit a combination of the two. The variety of descriptive means, as well as the conceptual complexity of semantic description to begin with, necessitates that OntoSem lexicons be compiled primarily manually. However, once a semantic description is created for a lexeme in one language, it can be reused in others, often with little or no modification. Said differently, the challenge in building a semantic lexicon is describing semantics; once the semantics are described, it is relatively straightforward to connect given meanings to the appropriate head words in other languages. In this paper we provide a brief overview of the OntoSem lexicon and processing environment, orient our approach to lexical semantics among others in the field, and describe in more detail what we mean by the largely language-independent lexicon. Finally, we suggest reasons why our resources might be of interest to the larger community.