What's in a Name? The Time Has Come to Unify Parkinson's Disease and Dementia with Lewy Bodies

Single-Cell Peripheral Immunoprofiling of Lewy Body Disease in a Multi-site Cohort

“…The medical and pathological distinctiveness of the LBD subgroups, PD, PDD, and LBD, is a decades-long debate 5 . We sought to determine the extent to which peripheral immune responses as measured here may potentially point to LBD subgroup-specific features.…”

“…Lewy Body Disease (LBD) comprises a spectrum of clinically and pathologically overlapping conditions: Dementia with Lewy Bodies (DLB) and Parkinson's Disease (PD) with or without Dementia (PDD) [1][2][3][4][5] . Human genetic, biochemical, and pathological evidence, as well as experimental models, support involvement not only by neuroinflammation [6][7][8] but also a peripheral immune response in the initiation and/or progression of LBD 6,[9][10][11][12][13] .…”

Genetic analysis of the X chromosome in people with Lewy body dementia nominates new risk loci

“…Additionally, the most up-to-date Parkinson’s disease diagnostic criteria no longer exclude dementia 48 , and the research criteria for the prodromal stages of Parkinson’s disease and dementia with Lewy bodies overlap 24 , 49 . Thus, due to the clinical similarities alongside difficulties in recruiting this group of individuals, studies may focus on LBD, the umbrella term, instead, and we have followed this approach 50 . Clinical profiles of dementia with Lewy bodies and Alzheimer’s can also overlap, with higher rates of misdiagnosis for females 1 , 5 .…”

“…The step function uses the Akaike information criterion (AIC) in a stepwise algorithm to determine which covariates fits the model best 59 . The covariates from the model with the lowest AIC were selected for adjustment in the association analysis 50 . For the overall cohort (i.e., males and females combined), age, sex, and five principal components (PC1, PC3, PC4, PC5, PC7) were included as covariates in the regression analysis.…”