What Roles Do Probiotics Play in the Eradication of Helicobacter pylori? Current Knowledge and Ongoing Research

Abstract

With the rising global prevalence of antibiotic resistance, the eradication rate of Helicobacter pylori (HP) is continuing to decrease. Probiotics are beneficial to human health and may be an adjunct therapy to increase the eradication rate of HP, lower treatment-associated side effects, and reduce HP-associated gastric inflammation. However, inconsistent test results have prevented conclusions about the therapeutic prowess of probiotics for HP. The mechanisms of actions of probiotics include the production of substances that inhibit or kill HP or compete with HP for the adhesion site on gastric epithelial cells. Probiotics can also reduce the release of inflammatory factors by regulating the local immune response of the host. We searched the available literature for full-length articles focusing on the role of probiotics in HP management. This review presents the latest advances in this area.

Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra

“…However, H. pylori adhesion and a reduced inflammatory response was shown. Other researchers reported also that probiotics alone could not completely eliminate H. pylori , but could reduce the load of H. pylori in the stomach, and alleviate gastric mucosal inflammation [ 46 , 47 ]. Accumulating evidence suggests an important role of IL-8 in H. pylori infection-associated chronic atrophic gastritis, peptic ulcer and gastric cancer [ 48 ].…”

Application of bacteriocins in food preservation and infectious disease treatment for humans and livestock: a review

“…100 Furthermore, nisin was demonstrated to be used in the treatment of lung infections and stomach ulcers to inhibit the growth of P. aeruginosa and Helicobacter pylori, respectively. 101 In addition, nisin A was proved to be an alternative agent used in the treatment of cancer. Nisin A can be used to reduce tumorigenesis by inducing preferential apoptosis, and the combination of nisin with doxorubicin was claimed to be an effective agent used in the reduction of tumour severity in skin carcinogenesis.…”

Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori

“…25 Moreover, several studies have confirmed different effects of H. pylori on the other apoptosis-involved genes such as AKT, Tp53, and IL-6. [26][27][28] Here, we evaluated the anti-apoptotic effects of the locally isolated probiotic bacterium L. plantarum on the AGS in the presence of H. pylori. We also evaluated the expression levels of apoptotic and anti-apoptotic related signaling pathways in the presence of L. plantarum, H. pylori, and co-culture of two mentioned bacteria on the AGS and Huvec cells to study the apoptotic and antiapoptotic signaling pathways in H. pylori.…”