What moderator characteristics are associated with better prognosis for depression?

Abstract

Abstract:A retrospective data analysis was conducted to evaluate the usefulness of baseline characteristics in predicting treatment response to antidepressant medication in 97 outpatients with nonpsychotic major depression treated for up to sixteen weeks with nefazodone. Baseline demographics (gender), illness features (symptom severity, length of illness, length of current episode, number of episodes, age of onset, longitudinal subtype, endogenicity, melancholia, family history of mood disorders), and social features (living status) were evaluated. Response to treatment was defined as a ≥ 50% reduction in the 17-item Hamilton Rating Scale for Depression (HRSD 17 ) score. The results of a survival analysis indicated that patients with shorter histories of illness (< 4 years), a negative family history of depression, and those who were either married or were living with someone were more likely to have a positive outcome during the acute phase treatment of depression. The main findings are consistent with extensive previous literature indicating a better short-term outcome of depression where illness is shorter, where there is no family history, and where there is better social support.

Szociodemográfiai hatótényezők vizsgálata unipoláris major depresszió kezelésében egy utánkövetéses klinikai vizsgálatban

“…Mintánkban a házas betegek szignifikánsan kisebb pontszámot értek el a nyolc-és a 12 hetes kezelés után, mint a nem házas (egyedülálló vagy elvált) betegek, annak ellenére, hogy a beutalás időpontjában mindkét kategória pontszáma hasonló volt. Adataink összhangban vannak a legújabb ku- tatási eredményekkel, amelyek szerint a családi állapot összefügg a depressziós tünetek csökkenésével [26], ugyanakkor a családi állapot (házas vagy együttélés) a jobb kezelésre adott válasz előrejelzője, az egyedül élők-kel (egyedülállók, elváltak, özvegyek) szemben [27]. Úgy tűnik, a családi állapot a nonremisszió védőfaktora-ként működik [28].…”

Remission and recovery in depression treatment

“…Treatment outcomes may be enhanced if pharmacotherapy is augmented with social support. For example, there is evidence that being married or living together may have a profound positive effect on overall response rates and the willingness to remain in treatment, even in the absence of response [Trivedi et al, 2005a].…”

Diurnal mood variation in outpatients with major depressive disorder

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Several clinical features have been consistently associated with a positive outcome to antidepressant medications, including lower severity of depressive symptoms, later age at onset, fewer previous depressive episodes, shorter length of illness, and greater social support. [17][18][19][20] At the symptom level, there has been a great deal of focus on endogenous depression, currently best represented in the criteria for melancholic depression.…”