What Matters in the Results of Repeated Intravenous Thrombolysis for Recurrent Ischemic Stroke?

Repeated Intravenous Thrombolysis in Patients with Recurrent Ischemic Stroke in the Vertebrobasilar Territory

“…Topakian et al [12] reported the use of IVT repeatedly up to 90 h in the case of recurrent IS in the anterior circulation, and recently, Bouchal et al [13] reported recurrent IS in the anterior circulation. Wu et al [14] reported 57 cases with the time interval between repeated administration of IVT <14 days only in 20 of them (in 10 of them within 48 h). The risk of cerebral hemorrhagic complications after IVT was reported significantly lower in the VB territory compared to anterior circulation [15,16], and it may be suggested that also risk of hemorrhagic complications after repeated IVT could be lower in IS in the VB territory.…”

“…Topakian et al [12] reported the use of IVT repeatedly up to 90 h in the case of recurrent IS in the anterior circulation, and recently, Bouchal et al [13] reported recurrent IS in the anterior circulation. Wu et al [14] reported 57 cases with the time interval between repeated administration of IVT <14 days only in 20 of them (in 10 of them within 48 h).…”

Repeated intravenous thrombolysis in recurrent ischemic stroke: a case report and review from the literature

“…Regardless of normal trans-thoracic echocardiography, in patients with AF rhythm, transesophageal echocardiography may be helpful. Wu et al conducted a systemic literature review in PubMed up to December, 2015 10 . A total of 15 studies involving 57 cases and 61 randomized trials (RTs) were collected.…”

Does Stroke Severity for Repeated Thrombolysis Matter? Response to the Letter by Wu et al.

“…From a statistical point of view, this approach is incorrect. Against this background and because the 15 observational studies that were used inDear Sir, We appreciate Dr. Wu's interest in our article [1,2] . By analyzing a comparatively large cohort of ischemic stroke patients repeatedly treated with tissue-type plasminogen activator (rt-PA) at a single center and by applying standard treatment procedures and outcome measures, we observed that repeated thrombolysis was not associated with a higher rate of complications compared to complications that arose as a result of the first treatment, but our data indicated that the clinical outcome after the second treatment appeared not to be as satisfactory as the outcome of the first treatment [1] .…”