What is your diagnosis? Peripheral blood smear and splenic fine‐needle aspirate from a cat

Conrado, Francisco de Oliveira; Stern, Jere K.; Griffin, Francesca C.

doi:10.1111/vcp.12817

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…21,22 Interestingly, a case report of M. haemofelis infection has also shown the presence of lymphocyte cannibalism of red blood cells. 23 To our knowledge, the presence of lymphocytes engulfing erythrocytes is a rare finding and can be associated with neoplasia 24,25 or M. haemofelis infection, 23 but the mechanism of this phenomenon is unclear.…”

Section: Cell Cannibalismmentioning

confidence: 99%

Hemophagocytic syndrome in a cat with Mycoplasma haemofelis infection

Strandberg

Tang

Santos

2023

Veterinary Clinical Pathol

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A six‐year‐old, castrated male domestic shorthair cat was presented for a week‐long history of lethargy, acute anorexia, and adipsia. On presentation, the cat was weak with pale mucous membranes, open‐mouth breathing, and mild popliteal lymphadenomegaly. Routine bloodwork revealed bicytopenia due to marked non‐regenerative anemia and moderate thrombocytopenia; erythrocyte clumping was apparent on the blood smear, but no agglutination was noted on a saline dispersion test. Abdominal and thoracic imaging showed marked splenomegaly and multiple mildly enlarged lymph nodes. Aspirates from the bone marrow and spleen contained many erythrophagocytic macrophages and occasional lymphocytes containing engulfed erythrocytes. The macrophages also occasionally contained phagocytosed erythroid precursors, platelets, and leukocytes. A diagnosis of hemophagocytic syndrome was made based on the presence of bicytopenia and increased numbers of hemophagocytic macrophages in the spleen and bone marrow. Though no organisms were observed, Mycoplasma spp. infection was suspected and confirmed via PCR. To the authors' knowledge, this is the first report of a hemophagocytic syndrome in a cat with Mycoplasma haemofelis. Lymphocyte engulfment of erythrocytes has been previously reported in a cat with M. haemofelis infection. Both hemophagocytic syndrome and engulfment of erythrocytes by lymphocytes should prompt testing for Mycoplasma spp. even with a lack of evident parasitemia.

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Section: Cell Cannibalismmentioning

confidence: 99%

Hemophagocytic syndrome in a cat with Mycoplasma haemofelis infection

Strandberg

Tang

Santos

2023

Veterinary Clinical Pathol

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“…Weitere Fälle von Erythrozyten-phagozytierenden neoplastischen Zellen bei der Katze beziehen sich insbesondere auf Mastzelltumore der Milz [24]. Zudem wurde die Aufnahme von Erythrozyten durch lymphatische Blasten in der reaktiv hyperplastischen Milz einer Katze mit einer Infektion mit hämotrophen Mykoplasmen (Mycoplasma haemofelis) beobachtet [27].…”

Section: Aus Wissenschaftlichem Interesse Erfolgte Im Vorliegenden Fa...unclassified

Zytologischer Nachweis eines hepatozytotropen T-Zell-Lymphoms bei einem 15 Jahre alten Kater

Finsterhölzl,

Müller,

Gaum

et al. 2023

Tierarztl Prax Ausg K Kleintiere Heimtiere

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ZusammenfassungDie Kasuistik beschreibt ein seltenes Phänomen der Emperipolese-ähnlichen Invasion von lymphatischen Blasten in die Hepatozyten eines 15 Jahre alten Europäisch Kurzhaar-Katers. Der Kater wurde mit unspezifischen Symptomen (Inappetenz und Gewichtsverlust) vorgestellt. Die zytologische Untersuchung eines ultraschallgestützt entnommenen Feinnadelaspirates der Leber zeigte einige Hepatozyten mit einer Emperipolese-ähnlichen Invasion von lymphatischen Blasten. Ganz vereinzelte extrazellulär gelegene lymphatische Blasten wiesen eine Erythrophagie auf. Nach der zytologischen Diagnosestellung eines großzelligen Lymphoms wurde der Kater nach einer zweiwöchigen Monotherapie mit Prednisolon aufgrund seines schlechten Allgemeinbefindens euthanasiert. Zur Bestätigung der zytologischen Verdachtsdiagnose eines hepatozytotropen Lymphoms erfolgte eine postmortale Probenentnahme aus der Leber. Die Histopathologie konnte die zytologischen Befunde bestätigen. Immunhistochemisch waren die lymphatischen Zellen CD3 positiv, sodass die Diagnose eines bisher nur selten beschriebenen hepatozytotropen T-Zell-Lymphoms gestellt werden konnte.

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“…The 52 reports deemed neutral to the PECO question included 396 cats in total with suspected IMHA in all of its forms (primary and secondary IMHA, pure red blood cell aplasia [PRCA] and nonregenerative immune‐mediated hemolytic anemia [NRIMHA]). There was no report of thrombosis in any of these studies 32–83 . In addition, these 52 reports included multiple other studies describing arterial and venous thrombosis in cats.…”

Section: Peco Question: Immune‐mediated Hemolytic Anemia (Imha) (Cats)mentioning

confidence: 99%

2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1‐ Defining populations at risk

deLaforcade

Bacek

Blais

et al. 2022

J Vet Emergen Crit Care

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Objectives: To expand the number of conditions and interventions explored for their associations with thrombosis in the veterinary literature and to provide the basis for prescribing recommendations. Design: A population exposure comparison outcome format was used to represent patient, exposure, comparison, and outcome. Population Exposure Comparison Outcome questions were distributed to worksheet authors who performed comprehensive searches, summarized the evidence, and created guideline recommendations that were reviewed by domain chairs. The revised guidelines then underwent the Delphi survey process to reach consensus on the final guidelines. Diseases evaluated in this iteration included heartworm disease (dogs and cats), immune-mediated hemolytic anemia (cats), protein-losing nephropathy (cats), protein-losing enteropathy (dogs and cats), sepsis (cats), hyperadrenocorticism (cats), liver disease (dogs), congenital portosystemic shunts (dogs and cats) and the following interventions: IV catheters (dogs and cats), arterial catheters (dogs and cats), vascular access ports (dogs and cats), extracorporeal circuits (dogs and cats) and transvenous pacemakers (dogs and cats).Results: Of the diseases evaluated in this iteration, a high risk for thrombosis was defined as heartworm disease or protein-losing enteropathy. Low risk for thrombosis was defined as dogs with liver disease, cats with immune-mediated hemolytic anemia, protein-losing nephropathy, sepsis, or hyperadrenocorticism. Conclusions:Associations with thrombosis are outlined for various conditions and interventions and provide the basis for management recommendations. Numerous knowledge gaps were identified that represent opportunities for future studies.

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What is your diagnosis? Peripheral blood smear and splenic fine‐needle aspirate from a cat

Cited by 3 publications

References 6 publications

Hemophagocytic syndrome in a cat with Mycoplasma haemofelis infection

Hemophagocytic syndrome in a cat with Mycoplasma haemofelis infection

Zytologischer Nachweis eines hepatozytotropen T-Zell-Lymphoms bei einem 15 Jahre alten Kater

2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1‐ Defining populations at risk

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