What is the source of anticontractile factor released by the pedicle of human internal thoracic artery?

Kociszewska, Karolina; Malinowski, Marcin; Czekaj, Piotr; Deja, Marek

doi:10.1093/icvts/ivv142

Cited by 3 publications

(8 citation statements)

References 23 publications

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Section: Introductionsupporting

confidence: 54%

“…Our previous studies confirmed that the perivascular tissue of the human internal thoracic artery (ITA) exerts an anticontractile effect on the underlying vascular wall and that this effect is associated with the release of adventitia or adipocyte-derived relaxing factor (ADRF)/perivascular tissue-derived relaxing factor (PVRF) [ 7 , 8 ]. ADRF, first described by Soltis and Cassis in 1991, attenuates the constrictive vascular response to plenty of vasoactive agents, independently of the endothelium and NO or prostacyclin release [ 4 , 7 , 9 ]. It acts by activating the potassium channels: K v in the mesenteric arteries of rats and mice; KCNQ delayed-rectifier Ca2+-sensitive large-conductance potassium channel (K Ca ) in the aortas of rats and mice; and the adenosine triphosphate-dependent potassium channel (K ATP ) in humans, where it potentially participates in ADRF-mediated relaxation [ 10 , 11 ].…”

Section: Introductionsupporting

confidence: 54%

“…Most of the current research concentrates on the role of ADRF in animal vascular beds: the rat mesenteric bed or the mouse aorta [ 7–10 , 15 ]. These studies triggered the search for the possible vasorelaxing role of perivascular tissue in humans.…”

Section: Discussionmentioning

confidence: 99%

“…It acts by activating the potassium channels: K v in the mesenteric arteries of rats and mice; KCNQ delayed-rectifier Ca2+-sensitive large-conductance potassium channel (K Ca ) in the aortas of rats and mice; and the adenosine triphosphate-dependent potassium channel (K ATP ) in humans, where it potentially participates in ADRF-mediated relaxation [ 10 , 11 ]. We concluded that harvesting the ITA as a pedicle might therefore be beneficial [ 7 , 8 ]. Whether perivascular fat surrounding the RA is also a source of ADRF remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Vasorelaxing properties of the perivascular tissue of the human radial artery

Kociszewska

Deja

Malinowski

et al. 2022

European Journal of Cardio-Thoracic Surgery

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OBJECTIVES Perivascular adipose tissue (PVAT) surrounding the human internal thoracic artery exhibits anticontractile and vasorelaxing properties associated with the adipocyte-derived relaxing factor (ADRF). The goal of our study was to assess if perivascular tissue of the human radial artery (RA) also exhibits such anticontractile/vasorelaxant properties. It could be especially relevant in preventing RA spasms. METHODS The study was performed on isolated segments of human pedicled RA. Its skeletonized fragments were suspended on stainless steel wire hooks and gradually contracted with serotonin to establish the concentration–effect relationship in the presence/absence of PVAT. Skeletonized arterial segments were precontracted with a single dose of 10−6 M serotonin (EC80). The 5-ml PVAT aliquots (from PVAT incubated in Krebs–Henseleit solution) were transferred to the RA tissue bath resulting in its relaxation. Subsequently, we investigated if ADRF is dependent on endothelial vasorelaxants (nitric oxide and prostacyclin). We attempted to find the potassium channel responsible for mediating the activity of ADRF using different potassium channel blockers. RESULTS RA without PVAT contracted more strongly in response to serotonin compared to RA with PVAT [Emax: 108.3 (20.2) vs 76.1 (13.5) mN]. The PVAT aliquot relaxed precontracted RA rings at 43% (2.4%) [72.2 (15.6) to 41.0 (5.6) mN]. ADRF is independent of endothelial vasorelaxants; hence, the addition of NG-monomethyl-L-arginine and indomethacin did not change the vasorelaxant response. Neither of the potassium channel blockers participated in the activity of ADRF. CONCLUSIONS PVAT of human RA exhibits anticontractile/vasorelaxant properties that are inherently associated with ADRF secretion. We confirmed the endothelial-independent mechanism of the activity of ADRF. However, we failed to find the potassium channel responsible for the action of ADRF.

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Section: Introductionsupporting

confidence: 54%

Section: Introductionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Vasorelaxing properties of the perivascular tissue of the human radial artery

Kociszewska

Deja

Malinowski

et al. 2022

European Journal of Cardio-Thoracic Surgery

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“…During follow-up, angina returned in 95 patients, 24 of whom required reintervention (20 cases of percutaneous balloon angioplasty and 4 reoperations). Postoperative coronary angiography performed in 87 patients revealed an IMA patency rate of 91% Kociszewska et al 20) Study of arterial segments of pedicled LIMA. Specimens were obtained from 20 patients undergoing CABG.…”

Section: Patencymentioning

confidence: 99%

Up-to-Date, Skeletonized or Pedicle Bilateral Internal Mammary Artery; Does It Matter?

Parissis

2023

ATCS

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In this article, we reported on the up-to-date literature regarding skeletonized bilateral internal mammary artery (BIMA) flow and the effect on sternal perfusion. We also reviewed the pros and cons of the skeletonization technique versus the conventional pedicle technique for harvesting the BIMA. Methods: We performed an up-to-date review using the PubMed database, with a specific focus on the contemporary published literature. Results: BIMA skeletonization can preserve the sternal microcirculation, minimize tissue damage, and maintain blood supply to the chest wall at the tissue level. This effect is also apparent in diabetics. Deep sternal wound infection (DSWI) rates are significantly less with skeletonization versus the conventional pedicle technique and are comparable to single internal mammary artery harvesting. Conclusions: Contemporary large-scale studies demonstrate that skeletonization of the BIMA increases conduit length, provides superior flow, reduces the incidence of DSWIs, and improves late survival. Hopefully, this review will increase awareness of the compelling evidence in favor of using skeletonized internal mammary arteries and stimulate increased uptake of BIMA revascularization surgery.

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Adipose-Vascular Coupling and Potential Therapeutics

Gollasch

2017

Annu. Rev. Pharmacol. Toxicol.

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Excess visceral adipose tissue is associated with increased risk of high blood pressure, lipid disorders, type 2 diabetes, and cardiovascular disease. Adipose tissue is an endocrine organ with multiple humoral and metabolic roles in regulating whole-body physiology. However, perivascular adipose tissue (PVAT) also plays a functional role in regulating the contractile state of the underlying smooth muscle cell layer. Work during the past decade has shown that this adipose-vascular coupling is achieved by production of numerous substances released from PVAT. Animal disease models have been instrumental in identifying biological and pathophysiological functions of this regulation. These studies have produced strong evidence that alterations in the paracrine control of PVAT in the regulation of arterial tone contribute to vascular dysfunction in obesity, hypertension, and cardiometabolic disease. Perivascular relaxing factors, or perhaps their putative targets, might represent exciting new targets for the prevention and treatment of cardiovascular and metabolic diseases.

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What is the source of anticontractile factor released by the pedicle of human internal thoracic artery?

Abstract: Adipose tissue from the pedicled ITA graft is an unlikely source of ADRF.

Cited by 3 publications

References 23 publications

Vasorelaxing properties of the perivascular tissue of the human radial artery

Vasorelaxing properties of the perivascular tissue of the human radial artery

Up-to-Date, Skeletonized or Pedicle Bilateral Internal Mammary Artery; Does It Matter?

Adipose-Vascular Coupling and Potential Therapeutics

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