Curve estimation techniques were used to identify the pattern of therapeutic change in female rape victims with posttraumatic stress disorder (PTSD). Within-session data on the Posttraumatic Stress Disorder Symptom Scale were obtained, in alternate therapy sessions, on 171 women. The final sample of treatment completers included 54 prolonged exposure (PE) and 54 cognitive-processing therapy (CPT) completers. For both PE and CPT, a quadratic function provided the best fit for the total PTSD, reexperiencing, and arousal scores. However, a difference in the line of best fit was observed for the avoidance symptoms. Although a quadratic function still provided a better fit for the PE avoidance, a linear function was more parsimonious in explaining the CPT avoidance variance. Implications of the findings are discussed.The purpose of controlled therapy outcome research is to identify specific cause-and-effect relationships that increase knowledge of mechanisms of change for affecting psychopathology and, consequently, allow for the development of increasingly effective psychotherapies (Borkovec & Miranda, 1999). Although comparisons of treatment with no-treatment conditions allow one to rule out the role of history, maturation, repeated testing, and statistical regression as explanatory factors for differences in treatment outcome, comparisons of treatment with placebo or a minimal-attention group allow one to conclude that something specific to the treatment condition, above and beyond the general therapeutic relationship, is responsible for therapeutic change (Borkovec & Castonguay, 1998).Once the efficacy of a new therapy is established in the initial stages through controlled trials, comparative designs are generally used to determine whether the therapy is superior to another treatment or matches the outcome of an already established treatment with adequate statistical power. Although comparative designs are useful for demonstrating empirical support for a new therapy, these designs are confounded by the fact that the two compared therapies are inherently different in a large number of ways. However, the results of comparative studies are useful in that they can help both of the treatments in question evolve and change on the basis of new clinical and empirical knowledge that is obtained over the course of the clinical trial (Devilly & Foa, 2001;Tarrier, 2001).Treatment-outcome research with female rape victims has largely involved the use of controlled and comparative trials. Two of the more researched treatments used with this population are prolonged exposure therapy (PE;Foa et al., 1999; Murdock, 1991) and cognitive-processing therapy (CPT; Resick & Schnicke, 1992. Clinical trials conducted with these therapies established the initial efficacy for both these treatments (Foa et al., 1991Resick & Schnicke, 1992. More recently, Resick, Nishith, Weaver, Astin, and Feuer (2002) conducted a clinical trial comparing PE and CPT with a minimal-attention (MA) control group. Although both therapies proved to b...