Abstract:Nociceptive dorsal root ganglion (DRG) and trigeminal neurons express a large numbers of ion channels that determine their threshold and responses to both noxious and innocuous stimuli.1 Several voltage-gated sodium channels (Nav),2 voltage-gated calcium (Ca2+) channels,3 transient receptor potential (TRP) channels,4 and other cation channels increase nociceptor responsiveness, whereas a variety of potassium (K+) channels prevent spontaneous nociceptor activity and reduce their firing probability.5-9 The imbal… Show more
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