What is the role of phenolic compounds of yerba mate (Ilex paraguariensis) in gut microbiota?

Santos, Daiane Rodrigues dos; Frota, Elionio Galvão; Vargas, Bruna Krieger; Gris, Cintia Cassia Tonieto; Santos, Lára Franco dos; Bertolin, Telma Elita

doi:10.1016/j.phytochem.2022.113341

Cited by 7 publications

(3 citation statements)

References 101 publications

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“…Moreover, a relationship between the consumption of polyphenols and an increase in beneficial microbiota has been well described [ 65 ]. Furthermore, several studies have shown that YM can modulate microbiota [ 66 , 67 ]. Since YM seems to work not directly toward macrophage polarization but by favoring changes in the microenvironment, we can speculate that polyphenols, particularly phenolic acid, promote M2 macrophage polarization and reduce inflammation by modulating gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Yerba Mate (Ilex paraguariensis) Reduces Colitis Severity by Promoting Anti-Inflammatory Macrophage Polarization

Olate-Briones,

Albornoz-Muñoz,

Rodríguez-Arriaza

et al. 2024

Nutrients

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Yerba Mate (YM) (Ilex paraguariensis) is a natural herbal supplement with a well-described anti-inflammatory capacity and beneficial effects in different inflammatory contexts such as insulin resistance or obesity. However, whether YM could improve other inflammatory conditions such as colitis or the immune cell population that can be modulated by this plant remains elusive. Here, by using 61 male and female C57BL/6/J wild-type (WT) mice and the dextran sodium sulfate (DSS)-induced acute colitis model, we evaluated the effect of YM on colitis symptoms and macrophage polarization. Our results showed that the oral administration of YM reduces colitis symptoms and improves animal survival. Increasing infiltration of anti-inflammatory M2 macrophage was observed in the colon of the mice treated with YM. Accordingly, YM promoted M2 macrophage differentiation in vivo. However, the direct administration of YM to bone marrow-derived macrophages did not increase anti-inflammatory polarization, suggesting that YM, through an indirect mechanism, is able to skew the M1/M2 ratio. Moreover, YM consumption reduced the Eubacterium rectale/Clostridium coccoides and Enterobacteriaceae groups and increased the Lactobacillus/Lactococcus group in the gut microbiota. In summary, we show that YM promotes an immunosuppressive environment by enhancing anti-inflammatory M2 macrophage differentiation, reducing colitis symptoms, and suggesting that YM consumption may be a good cost-effective treatment for ulcerative colitis.

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Section: Discussionmentioning

confidence: 99%

Yerba Mate (Ilex paraguariensis) Reduces Colitis Severity by Promoting Anti-Inflammatory Macrophage Polarization

Olate-Briones,

Albornoz-Muñoz,

Rodríguez-Arriaza

et al. 2024

Nutrients

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“…These compounds are responsible for several functional properties closely related with the prevention of certain oxidative processes, which are, in turn, responsible for inflammatory pathologies, cancer, neurodegenerative and cardiovascular diseases [1,2]. They also improve the intestinal barrier integrity down-regulating various inflammatory molecules [3] and modulate the intestinal microbiota [4]. Apart from the aforementioned functional traits, these metabolites play a central role in several sensory characteristics Plants 2023, 12, 1646 2 of 21 such as colour, flavour, bitterness and astringency in beverages, such as beer, cider, wine and tea or plant infusions, as well as in foods [5].…”

Section: Introductionmentioning

confidence: 99%

Powdered Beverage from Native Plants from Argentina (Zuccagnia punctata and Solanum betaceum) Obtained by Spray-Drying: A Promising Source of Antioxidant Compounds

Uriburu

Zampini

Maldonado

et al. 2023

Plants

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In previous studies, the Argentinean native plants called Zuccagnia punctata (jarilla, pus pus, lata) and Solanum betaceum (chilto, tree tomato) were reported as new natural sources of antioxidant compounds, mainly chalcones, anthocyanins and rosmarinic acid derivates. The present study deals with the production of antioxidant beverages of Z. punctata (Zp) extract and chilto juice with honey as sweetener. A Zp extract and red chilto juice were obtained according to Food Code and characterized. The beverages were formulated by using maltodextrin (MD) with two dextrose equivalents (DE), 10 and 15, and then spray-dried at an inlet air temperature of 130 °C. The physicochemical, microscopical, phytochemical and functional characteristics of the powders were surveyed. The experiments carried out showed good physical properties for both formulations showing high water solubility with adequate features for handling, transport and storage. The chromatic parameters of both powdered beverages indicate orange–pink tones regardless of the wall material used. The total polyphenol and flavonoid content in the beverages were kept after spray-drying (92 and 100%, respectively). The anthocyanins were less stable under drying conditions (yield 58%). Both powdered beverages showed high scavenger capacity on ABTS•+, HO• and H2O2 (SC50 between 3.29 to 41.05 µg GAE/mL) and were able to inhibit xanthine oxidase (XOD) activity (CI50 between 91.35 and 114.43 µg GAE/mL). The beverages were neither toxic nor mutagenic in the concentration range with biological activity. The results obtained in the present work scientifically support the use of the powdered beverages of Argentinean native plants as antioxidant.

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“…• Affecting microbiota in human digestive system which play an important role in food digestion and fat metabolism [2,26,27].…”

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confidence: 99%

Can Yerba Maté (Ilex paraguariensis A.-St.-Hil) and Its Constituents Affect Health and Obesity?

Sirotkin

2024

J Cell Signal

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The present commentary is a short narrative review of the available data concerning the influence of Yerba Maté, its relatives and constituents on health with special attention to its anti-obesity effects and their physiological mechanisms. The possible adverse side-effects of Yerba Maté, form and doses of its consumption are discussed. The available information demonstrates the ability of Yerba Maté and its constituents to prevent and to treat a wide array of disorders including obesity, although the potential of this plant to promote weight loss requires further elucidation.

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What is the role of phenolic compounds of yerba mate (Ilex paraguariensis) in gut microbiota?

Cited by 7 publications

References 101 publications

Yerba Mate (Ilex paraguariensis) Reduces Colitis Severity by Promoting Anti-Inflammatory Macrophage Polarization

Yerba Mate (Ilex paraguariensis) Reduces Colitis Severity by Promoting Anti-Inflammatory Macrophage Polarization

Powdered Beverage from Native Plants from Argentina (Zuccagnia punctata and Solanum betaceum) Obtained by Spray-Drying: A Promising Source of Antioxidant Compounds

Can Yerba Maté (Ilex paraguariensis A.-St.-Hil) and Its Constituents Affect Health and Obesity?

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