What is the role of between meal snacks with intensive basal bolus regimens using preprandial lispro?

Kong, N.; Ryder, Robert E.J.

doi:10.1046/j.1464-5491.1999.00082.x

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Use Of Rapid-acting Analogues For Common Paediatric Diabetol1

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2002

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“…Because of their shorter duration of action, analogues are associated with lower late morning insulin levels. As in adults [32], it may therefore be possible to reduce or omit a mid-morning snack, although this remains to be demonstrated in clinical studies.…”

Section: Use Of Rapid-acting Analogues For Common Paediatric Diabetolmentioning

confidence: 99%

Experience with Insulin Analogues in Children

et al. 2002

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Current data on rapid and long-acting insulin analogues in the paediatric age group is limited. While several studies indicate a benefit in reducing hypoglycaemia, particularly at night, with rapid or long-acting insulin analogue treatment, the effect on long-term glycaemic control remains controversial. The continuous glucose monitoring system offers a new option for tailoring treatment with insulin analogues to achieve optimal glycaemia. In 29 adolescents with diabetes this approach confirmed the non-inferiority of postprandial rapid-acting analogue administration compared to preprandial regular insulin, but revealed significant mealtime differences, with increased analogue requirement at breakfast and dinner. Although rapid- and long-acting insulin analogues may offer potential benefits for problems frequently encountered in paediatric diabetology, their value for the individual child still has to be tested in long-term observations in daily clinical practice.

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Section: Use Of Rapid-acting Analogues For Common Paediatric Diabetolmentioning

confidence: 99%