2011
DOI: 10.1007/s11886-011-0224-z
|View full text |Cite
|
Sign up to set email alerts
|

What is the Role of Aldosterone Excess in Resistant Hypertension and How Should It Be Investigated and Treated?

Abstract: Resistant hypertension has evolved as an important global health care problem. Primary aldosteronism is one of several potentially reversible causes of resistant hypertension. Primary aldosteronism can be effectively treated, when recognized, with a mineralocorticoid receptor antagonist, such as spironolactone and eplerenone. Each of these compounds can reduce blood pressure as monotherapy or when given with a range of other antihypertensive drug classes. These compounds have distinctive pharmacokinetic and ph… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2014
2014
2014
2014

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(2 citation statements)
references
References 50 publications
0
2
0
Order By: Relevance
“…1,23 Elevated aldosterone levels are associated with detrimental cardiovascular physiologic effects, such as oxidative stress, endothelial dysfunction, inflammation and tissue fibrosis. 24 Elevated activity of the sympathetic nervous system is also a key contributor to resistant hypertension. This excess activity is frequently present in primary (essential) hypertension.…”
Section: Which Factors Contribute To Resistant Hypertension?mentioning
confidence: 99%
See 1 more Smart Citation
“…1,23 Elevated aldosterone levels are associated with detrimental cardiovascular physiologic effects, such as oxidative stress, endothelial dysfunction, inflammation and tissue fibrosis. 24 Elevated activity of the sympathetic nervous system is also a key contributor to resistant hypertension. This excess activity is frequently present in primary (essential) hypertension.…”
Section: Which Factors Contribute To Resistant Hypertension?mentioning
confidence: 99%
“…Eplerenone, which has fewer sex-hormonedependent adverse effects (e.g., painful gynecomastia and erectile dysfunction), is a costlier and less potent alternative. 24 Amiloride, an epithelial sodium-channel blocker (not a mineralocorticoidreceptor antagonist), is another option and is used most commonly in primary aldosteronism. 52 Table 3).…”
Section: Renin Profilingmentioning
confidence: 99%