What is the potential of neurostimulation in the treatment of motor symptoms in schizophrenia?

Lefebvre, Stéphanie; Pavlidou, Anastasia; Walther, Sebastian

doi:10.1080/14737175.2020.1775586

Cited by 29 publications

(35 citation statements)

References 103 publications

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“…Although movement abnormalities are prevalent in schizophrenia affecting overall communication and social functioning very little has been done to treat and alleviate these deficits. Psychopharmacology has proven to have very little effects on psychomotor abnormalities, while NIBS has some promise (Lefebvre et al, 2020). In this perspective paper, we highlight VR's success in effectively combining all elements of ML in improving motor abnormalities in neurological disorders, and advocate its potential use in ameliorating, restoring, and improving movement abnormalities in schizophrenia patients.…”

Section: Future Outlook and Conclusionmentioning

confidence: 99%

“…Preliminary findings suggest non-invasive brain stimulation (NIBS) is a potential candidate in alleviating movement abnormalities in schizophrenia patients (Walther et al, 2020a,c). Several ongoing clinical trials are currently administered to further assess the efficacy of NIBS (Lefebvre et al, 2020); Personalized Non-invasive Neuromodulation by rTMS for Chronic and Treatment-Resistant Catatonia trial (RETONIC, NCT03116425), Overcoming Psychomotor Slowing in Psychosis trial (OCoPS-P, NCT03921450), and Brain Stimulation And Group Therapy to Improve Gesture and Social Skills in Psychosis trial (BrAGG-SoS, NCT04106427). Developing alternative interventions in tackling movement abnormalities may offer a better and long-term solution while addressing the concerns regarding usage of medication and their related side effects (Lieberman et al, 2005;Stegmayer et al, 2018).…”

Section: Treatment Options For Movement Abnormalitiesmentioning

confidence: 99%

“…Using ML, we can combine motor and socio-cognitive domains to establish personalized simulated real-life scenarios tailored to each patient's individual needs promoting autonomy that can greatly improve their quality of life, such as gesture performance. In addition, combining VR with NIBS can further benefit patients with schizophrenia as, neuromodulation of the affected cortical areas while being placed in a safe virtual environment, could allow for direct translation to the real world (Gainsford et al, 2020;Lefebvre et al, 2020).…”

Section: Future Outlook and Conclusionmentioning

confidence: 99%

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Using Virtual Reality as a Tool in the Rehabilitation of Movement Abnormalities in Schizophrenia

Pavlidou

Walther

2021

Front. Psychol.

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Movement abnormalities are prevalent across all stages of schizophrenia contributing to poor social functioning and reduced quality of life. To date, treatments are scarce, often involving pharmacological agents, but none have been shown to improve movement abnormalities effectively. Virtual reality (VR) is a tool used to simulate virtual environments where behavioral performance can be quantified safely across different tasks while exerting control over stimulus delivery, feedback and measurement in real time. Sensory information is transmitted via a head mounted display allowing users to directly interact with virtual objects and bodies using gestures and body movements in the real world to perform different actions, permitting a sense of immersion in the simulated virtual environment. Although, VR has been widely used for successful motor rehabilitation in a variety of different neurological domains, none have been exploited for motor rehabilitation in schizophrenia. The objectives of this article are to review movement abnormalities specific to schizophrenia, and how VR can be utilized to restore and improve motor functioning in patients with schizophrenia. Constructing VR-mediated motor-cognitive interventions that can help in retaining and transferring the learned outcomes to real life are also discussed.

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Section: Future Outlook and Conclusionmentioning

confidence: 99%

Section: Treatment Options For Movement Abnormalitiesmentioning

confidence: 99%

Section: Future Outlook and Conclusionmentioning

confidence: 99%

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Using Virtual Reality as a Tool in the Rehabilitation of Movement Abnormalities in Schizophrenia

Pavlidou

Walther

2021

Front. Psychol.

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“…As a matter of fact, neuromodulation is considered a promising therapeutic tool that promotes cognitive enhancement by increasing the ability of distributed cortical networks to coordinate and generates brain rhythms. The impairment of this oscillatory dynamics, which is referred to as oscillophaties, can result in altered behavioral outcomes, and has impact on several neurological and psychiatric disorders including schizophrenia, Alzheimer disease, Parkinson's disease, epilepsy and sleep disorders [6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Modelling neural entrainment and its persistence: influence of frequency of stimulation and phase at the stimulus offset

Otero

Lea‐Carnall

Prado

et al. 2021

Preprint

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The entrainment (synchronization) of brain oscillations to the frequency of sensory stimuli is a key mechanism that shapes perceptual and cognitive processes, such that atypical neural entrainment leads to neuro-psychological deficits. We investigated the dynamic of neural entrainment. Particular attention was paid to the oscillatory behavior that succeed the end of the stimulation, since the persistence (reverberation) of neural entrainment may condition future sensory representations based on predictions about stimulus rhythmicity. A modified Jansen-Rit neural mass model of coupled cortical columns generated a time series whose frequency spectrum resembled that of the electroencephalogram. We evaluated spectro-temporal features of entrainment, during and after rhythmic stimulation of different frequencies, as a function of the resonance frequency of the neural population and the coupling strength between cortical columns. We tested if the duration of the entrainment persistence depended on the state of the neural network at the time the stimulus ends. The entrainment of the column that received the stimulation was maximum when the frequency of the entrainer was within a narrow range around the resonance frequency of the column. When this occurred, entrainment persisted forseveral cycles after the stimulus terminated, and the propagation of the entrainment to other columns was facilitated. Propagation depended on the resonance frequency of the second column, and the coupling strength between columns. The duration of the persistence of the entrainment depended on the phase of the neural oscillation at the time the entrainer terminated, such that falling phases (from π/2 to 3π/2 in a sine function) led to longer persistence than rising phases (from 0 to π/2 and 3π/2 to 2π). The study bridges between models of neural oscillations and empirical electrophysiology, and provides insights to the use of rhythmic sensory stimulation for neuroenhancement.

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“…Finally, the development of brain stimulation techniques urges scientists to focus on the pathobiology of mental disorders. These novel treatments are grounded in knowledge on the pathophysiology of symptoms such as auditory verbal hallucinations, tinnitus, pain, or psychomotor slowing [7]. Further developments will require the test of brain stimulation effects on neurophysiology, the optimal dosing, protocol design, and perhaps the identification of the ideal candidate patients for brain stimulation [8], also for FDA approved rTMS applications for depression [9].…”

mentioning

confidence: 99%

Non-invasive brain stimulation: the next frontier in psychiatry

Walther

Baeken

2021

Eur Arch Psychiatry Clin Neurosci

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What is the potential of neurostimulation in the treatment of motor symptoms in schizophrenia?

Cited by 29 publications

References 103 publications

Using Virtual Reality as a Tool in the Rehabilitation of Movement Abnormalities in Schizophrenia

Using Virtual Reality as a Tool in the Rehabilitation of Movement Abnormalities in Schizophrenia

Modelling neural entrainment and its persistence: influence of frequency of stimulation and phase at the stimulus offset

Non-invasive brain stimulation: the next frontier in psychiatry

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