2003
DOI: 10.1111/j.0906-6705.2003.0109a.x
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What is the physiological function of mast cells?

Abstract: Under physiological conditions, skin mast cells preferentially localize around nerves, blood vessels and hair follicles. This observation, which dates back to Paul Ehrlich, intuitively suggests that these enigmatic, multifacetted protagonists of natural immunity are functionally relevant to many more aspects of tissue physiology than just to the generation of inflammatory and vasodilatory responses to IgE-dependent environmental antigens. And yet, for decades, mainstream-mast cell research has been dominated b… Show more

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Cited by 193 publications
(175 citation statements)
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“…Mast cells are well known mediators of injury-or infection-associated inflammation; however, recently additional functions for these cells have been suggested. In this respect, reports that suggest a role of mast cells in ECM-related processes during wound healing and fibrosis (Noli and Miolo, 2001;Puxeddu et al, 2003;Maurer et al, 2003) are of particular interest. Specifically, a role of mast cells in the aggregation of collagen fibers (Iba et al, 2004) or collagen lattice contraction (Moyer et al, 2004) has been investigated.…”
Section: Spherulocyte Role During Echinoderm Regenerationmentioning
confidence: 99%
“…Mast cells are well known mediators of injury-or infection-associated inflammation; however, recently additional functions for these cells have been suggested. In this respect, reports that suggest a role of mast cells in ECM-related processes during wound healing and fibrosis (Noli and Miolo, 2001;Puxeddu et al, 2003;Maurer et al, 2003) are of particular interest. Specifically, a role of mast cells in the aggregation of collagen fibers (Iba et al, 2004) or collagen lattice contraction (Moyer et al, 2004) has been investigated.…”
Section: Spherulocyte Role During Echinoderm Regenerationmentioning
confidence: 99%
“…9,12 It is generally believed that mast cells induce a fibrotic response via involvement of connective tissue fibroblasts and myofibroblasts. 9,12,15,16 It has been well described that the neuropeptides Substance P and CGRP can cause mast cell degranulation. 8,11,13,14,17,18 Peptidergic nerve terminalshavebeen detectedin close association with mast cells in skin, ligament, joint capsule, and the gut.…”
mentioning
confidence: 99%
“…25 The central nervous system can activate mast cells through classical conditioning, 26 and induce activation during times of stress. 22,27,28 In diseases such as experimental allergic encephalomyelitis (EAE), mast cells may produce chemotactic factors that can recruit nearby inflammatory cells such as T cells.…”
Section: Discussionmentioning
confidence: 99%