What is the optimal number of readers needed to achieve high diagnostic accuracy in coronary computed tomographic angiography? A comparison of alternate reader combinations

CT Angiography Followed by Invasive Angiography in Patients With Moderate or Severe Ischemia-Insights From the ISCHEMIA Trial

“…Elements of this study may limit the application to routine clinical CCTA or to more broad populations, particularly those with much lower a priori likelihood of CAD. The analyses were based upon core-laboratory assessment and were all determined by consensus (23). This element of quality control does not occur in routine practice.…”