What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis

Groenewoud, Eva R.; Cantineau, Astrid E. P.; Kollen, Boudewijn J.; Macklon, Nick S.; Cohlen, Ben J

doi:10.1093/humupd/dmw046

Cited by 94 publications

(132 citation statements)

References 6 publications

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“…144 Administering oestrogen from day 1 of the menstrual cycle suppresses FSH levels and therefore stops a dominant follicle developing, thus preventing spontaneous ovulation. 144 Administering oestrogen from day 1 of the menstrual cycle suppresses FSH levels and therefore stops a dominant follicle developing, thus preventing spontaneous ovulation.…”

Section: Controlled Fetmentioning

confidence: 99%

“…The dose used can be between 2 and 8 mg/day and is usually increased gradually until the endometrium is sufficiently thickened. 44,[144][145][146] As with natural FET, an endometrial lining that is <7-8 mm thick may result in a cancellation of FET. 145 Regular ultrasound scans are performed to monitor endometrial development.…”

Section: Controlled Fetmentioning

confidence: 99%

“…145 Regular ultrasound scans are performed to monitor endometrial development. 144 In women with functional ovaries, oestrogen medication may be insufficient to fully suppress the development of the dominant follicle. 145 When the endometrium is 7-9 mm thick, progesterone supplementation is added to initiate secretory changes in the endometrium.…”

Section: Controlled Fetmentioning

confidence: 99%

“…The scans start around day 9 or 10. 140,144,147 This approach has been shown to significantly increase live birth rates. 44,[144][145][146] As with natural FET, an endometrial lining that is <7-8 mm thick may result in a cancellation of FET.…”

Section: Controlled Fetmentioning

confidence: 99%

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Acupuncture during ART

Szmelskyj

2015

Acupuncture for IVF and Assisted Reproduction

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Section: Controlled Fetmentioning

confidence: 99%

Section: Controlled Fetmentioning

confidence: 99%

Section: Controlled Fetmentioning

confidence: 99%

Section: Controlled Fetmentioning

confidence: 99%

See 2 more Smart Citations

Acupuncture during ART

Szmelskyj

2015

Acupuncture for IVF and Assisted Reproduction

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“…[2][3][4][5] The critical issue regarding FET cycles is the synchronization between embryo transfer and the implantation window and optimal preparation of the endometrium to increase the implantation rate in these cycles. 1,6 Although there is no reliable evidence that one cycle regimen is superior to others, 7 recently Altmäe et al 1 reported that artificial-cycle frozen embryo transfer (AC-FET) had a significant negative impact on the endometrial 1 Some studies claimed that natural-cycle frozen embryo transfer (NC-FET) is a cheaper and more patient-friendly protocol as less medication for endometrial preparation is used.…”

Section: Introductionmentioning

confidence: 99%

Serum estradiol level on trigger day impacts clinical pregnancy rate in modified natural frozen embryo transfer cycles

Ramezanali

Arabipoor

Hafezi

et al. 2019

Intl J Gynecology & Obste

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Objective To examine the predictive value of serum estradiol and progesterone on the day of human chorionic gonadotropin (hCG) administration and embryo transfer for clinical pregnancy rate in modified natural‐cycle frozen embryo transfer (NC‐FET). Methods In a longitudinal prospective study, all eligible women who underwent NC‐FET cycles with hCG triggering in Royan Institute, Tehran, Iran, from June 1, 2015, to December 31, 2016, were evaluated. Serum estradiol and progesterone levels were measured at menstrual cycle initiation, on day of trigger with hCG, on day of embryo transfer, and in pregnant women every 7 days until the observation of a gestational sac with embryonic heartbeat. Results In total, 101 modified natural FET cycles were assessed, and the clinical pregnancy and live birth rates achieved were 34 (33.6%) and 32 (31.6%), respectively. The changes in estradiol level during early pregnancy showed an increase by an average of 200 pg/mL per week. Multivariable logistic regression analysis showed that only the estradiol level on the hCG day was a significant predictive variable for clinical pregnancy following NC‐FET (P=0.04). Conclusion Estradiol level on the day of hCG trigger predicted the clinical pregnancy rates after modified NC‐FET; this likely mirrored the developmental competence of the corpus luteum and an appropriate luteal structure‐function.

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Case of heterotopic cervical pregnancy and total placenta accreta after artificial cycle frozen‐thawed embryo transfer

Saito

Fukami

Miyado

et al. 2017

Reprod Medicine & Biology

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CaseA 39‐year‐old woman presented with a genital hemorrhage at 5 weeks of gestation after an artificial cycle double frozen‐thawed embryo transfer. She was diagnosed with a cervical heterotopic pregnancy. Although hormone supplementation was discontinued to terminate the pregnancy at 5 weeks of gestation, the intrauterine and cervical gestational sacs continued to develop.OutcomeThe cervical gestational sac was surgically removed and the intrauterine pregnancy continued uneventfully, except for vasa previa. At 36 weeks of gestation, the patient underwent a cesarean section and gave birth to a healthy female infant. At the delivery, massive bleeding occurred and a hysterectomy was performed due to total placenta accreta.ConclusionThis case provides a novel example of a near‐term delivery after a cervical heterotopic pregnancy and emphasizes the need for intensive care, even after the successful management of a cervical pregnancy. Most importantly, the present case implies a possible link between hormonal withdrawal and abnormal placentation.

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What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis

Cited by 94 publications

References 6 publications

Acupuncture during ART

Acupuncture during ART

Serum estradiol level on trigger day impacts clinical pregnancy rate in modified natural frozen embryo transfer cycles

Case of heterotopic cervical pregnancy and total placenta accreta after artificial cycle frozen‐thawed embryo transfer

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