What is the optimal goal of primary cytoreductive surgery for bulky stage IIIC epithelial ovarian carcinoma (EOC)?

Chi, D.S.; Eisenhauer, Eric L.; Lang, Jinghe; Huh, Jae; Haddad, Lisa; Abu‐Rustum, Nadeem R.; Sonoda, Yukio; Levine, Douglas A.; Hensley, Martee L.; Barakat, Richard R.

doi:10.1016/j.ygyno.2006.03.051

Cited by 548 publications

(252 citation statements)

References 27 publications

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“…In 2006, Chi et al analyzed 465 patients with bulky stage IIIC ovarian cancer who underwent attempted maximal cytoreductive surgery with extensive abdominal resections (diaphragm stripping/resection, splenectomy, distal pancreatectomy, liver resection, and resection of tumor from porta hepatitis), followed by a minimum of six cycles of postoperative platinum-based systemic chemotherapy. Patients with no gross RD after primary cytoreduction had a median survival of 106 months, and it was proposed that the resection of all visible disease significantly improved survival and should be the primary surgical goal of CS [9] . The impact of radical abdominal CS procedures (splenectomy, liver resection, extensive peritonectomy) on RD and the associated survival outcome of 194 patients with stage IIIC epithelial ovarian cancer receiving adjuvant platinum-based chemotherapy (including paclitaxel or cyclophosphamide) for six to eight cycles after undergoing primary surgery were analyzed [43] .…”

Section: Impact Of Extensive Abdominal Surgery On Survivalmentioning

confidence: 99%

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Digestive resections in advanced-stage ovarian cancer

Bacalbaşa

Ionescu²,

Ionescu

et al. 2016

Adv Mod Oncol Res

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Abstract:The standard frontline treatment for advanced-stage ovarian cancer (ASOC) consists of maximal cytoreduction surgery associated with platinum/paclitaxel-based chemotherapy. Several studies have proven that patients with no gross residual disease (RD) have better survival rates than those with optimal but visible RD (RD ≤1 cm). In order to achieve this, more radical cytoreductive procedures such as radical pelvic resection and extensive upper abdominal procedures are performed. However, some investigators have suggested that, although effective, radical surgery cannot fully compensate tumor biology, which is a major determinant in survival and in turn influences the likelihood of surgical cytoreduction. The aim of this review was to present the procedures defining ultra-radical (extensive) surgery and to evaluate its feasibility and morbidity in the management of ASOC.Keywords: ovarian cancer; residual disease; cytoreductive surgery

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Section: Impact Of Extensive Abdominal Surgery On Survivalmentioning

confidence: 99%

“…The minimum size of RD associated with a significant impact on survival is not exactly known but a large improvement in the prognosis is associated with the removal of all macroscopic tissues. There is a universally diverse surgical practice, with huge variations in the cytoreduction rate between 22% and 98% [9] .…”

Section: Introductionmentioning

confidence: 99%

Digestive resections in advanced-stage ovarian cancer

Bacalbaşa

Ionescu²,

Ionescu

et al. 2016

Adv Mod Oncol Res

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“…: медиана выживаемости составила 106 мес, при разме-ре остаточной опухоли ≤ 0,5 см -66 мес, 0,6-1,0 см -48 мес, > 1 см -33-34 мес. Статистически значимые различия были выявлены между группами пациенток с выполненной полной, оптимальной и неоптималь-ной циторедукцией (p < 0,01) [7].…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified

Optimizing the primary treatment of patients with advanced ovarian cancer

Никогосян¹,

Кузнецов²,

Загаштоков³

et al. 2016

Tumors of female reproductive system

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Г и н е к о л о г и я / G y n e c o l o g y о н стат и Введение Несмотря на успехи диагностики, примерно в 75 % наблюдений рак яичников (РЯ) выявляется на поздних стадиях заболевания [1]. Показатель 5-летней выжи-ваемости больных РЯ III стадии составляет 23,8 %, а IV -лишь 11,6 % [2]. Низкий уровень выживаемо-сти больных РЯ обусловлен в первую очередь распро-страненностью опухоли и, как следствие, нарушением функции жизненно важных органов и систем паци-ентки, наличием сопутствующих заболеваний. Эти факторы определяют высокий риск возникновения осложнений при выполнении радикальных хирурги-ческих вме шательств и проведении лекарственного лечения. В связи с этим определение стратегии пер-вичного комбинированного лечения больных распро-страненным РЯ является одним из трудных и дискута-бельных вопросов современной онкологии.Хирургическое вмешательство является ведущим методом лечения РЯ и выполняется как на ранних, так и на поздних стадиях болезни. Цели операции вклю-чают диагностику, уточнение степени распространен-ности опухоли и, самое главное, выполнение макси-мально возможной циторедукции.Достижение полной или оптимальной циторедук-ции у больных распространенным РЯ зачастую тре-бует от хирурга опыта работы не только в малом тазу,

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“…However, even in cases in which recurrence is diagnosed debulking surgery remains the therapeutic golden standard. When it comes to the upper abdominal involvement, although initially it has been considered that cases presenting upper abdominal tumor burden cannot be candidates for debulking surgery, improvement of the surgical techniques and of the postoperative management leaded to a widely introduction of these procedures as part of debulking surgery (3,4).…”

Section: Introductionmentioning

confidence: 99%

Extended upper abdominal resections as part of debulking surgery at the time of tertiary cytoreduction for relapsed ovarian cancer; case report and literature review

Bacalbaşa¹,

Bălescu²

2017

J Clin Invest Surg.

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Ovarian cancer remains one of the most aggressive gynecologic malignancies with high capacity to recur even in cases submitted to surgery with curative intent. However, even in these cases the best therapeutic option in order to achieve a good control of the disease remains radical surgery.We present the case of a 65-year-old patient diagnosed submitted to surgery for stage IIIC ovarian cancer five years before. At two years follow up she was diagnosed with an isolated recurrence at the level of the hepatic pedicle which was successfully removed. At 18 months follow up she was diagnosed with a large recurrence in the left superior abdominal quadrant and a liver metastasis which were resected. At 18 months follow up she is free of recurrent disease.Nicolae Bacalbașa et al. 76

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What is the optimal goal of primary cytoreductive surgery for bulky stage IIIC epithelial ovarian carcinoma (EOC)?

Cited by 548 publications

References 27 publications

Digestive resections in advanced-stage ovarian cancer

Digestive resections in advanced-stage ovarian cancer

Optimizing the primary treatment of patients with advanced ovarian cancer

Extended upper abdominal resections as part of debulking surgery at the time of tertiary cytoreduction for relapsed ovarian cancer; case report and literature review

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