What is the impact of Helicobacter pylori density on the success of eradication therapy: A clinico-histopathological study

The influence of vitamin D deficiency on eradication rates of Helicobacter pylori

“…15 Recent studies have shown higher H.pylori density by histopathology to be related with complications while indicating a negative correlation with H.pylori eradication rates. 16,17 Our study, however, found no significant difference. It is important to note that both of these studies used the triple therapy.…”

Different bismuth-based therapies for eradicating Helicobacter pylori: Randomized clinical trial of efficacy and safety

“…In our previous study, we compared H. pylori eradication rates of clarithromycin-based triple therapy and BCQT and observed 50% and 92% eradication, respectively [39]. In the present study, we observed a mild increase in eradication rates with the addition of bismuth to the standard clarithromycin-based triple therapy (ITT, 59.2%); however, this rate did not meet the required H. pylori eradication rate of >80%.…”

Colonization of Helicobacter pylori in the gastric cardia: A comparison between the UFT300 and CLO tests

“…Several studies have revealed that high antral density of H. pylori or intragastric bacterial load may affect the success of eradication therapy . A prospective case–control study demonstrated that the higher the H. pylori density, the less effective triple therapy will be for H. pylori eradication, and that quadruple therapy does not seem to be negatively affected by bacterial density . H. pylori colonization with a high bacterial load in the cardia, especially for patients with a positive UFT300 test, could be considered a risk factor for treatment failure, and it warrants a more effective treatment such as a prolonged 14‐day regimen and quadruple or concomitant therapy to improve the eradication rate.…”