What is the impact of BIRC5 gene polymorphisms on urinary cancer susceptibility? Evidence from 9348 subjects

Xu, Ming; Hu, Xianyu; Zhang, Meng; Ge, Yating

doi:10.1016/j.gene.2019.144268

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…In a study on the anticancer properties of FZD7 after pharmacological inhibition of HCC, it was suggested that the mechanism may be associated with PRKCD mutations (32). BIRC5 has been described as a negative regulator of apoptosis, and its expression was reported to be higher in most tumors including HCC (33)(34)(35)(36), which is consistent with our findings indicating that the expression of BIRC5 is higher in the high-risk group of HCC prognosis. Moreover, the potential influence of BIRC5, HMOX1, and VEGFA in the prognosis of HCC had been reported in studies by Wang et al(37), Shen et al (38), and…”

Section: Discussionsupporting

confidence: 91%

Identification of an autophagy-related gene signature predicting overall survival for hepatocellular carcinoma

Guo

Lü

et al. 2021

Bioscience Reports

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The poor prognosis of hepatocellular carcinoma (HCC) calls for the development of accurate prognostic models. The growing number of studies indicating a correlation between autophagy activity and HCC indicates there is a commitment to finding solutions for the prognosis of HCC from the perspective of autophagy. We used a cohort in The Cancer Genome Atlas (TCGA) to evaluate the expression of autophagy-related genes in 371 HCC samples using univariate Cox and lasso Cox regression analysis, and the prognostic features were identified. A prognostic model was established by combining the expression of selected genes with the multivariate Cox regression coefficient of each gene. Eight autophagy-related genes were selected as prognostic features of HCC. We established the HCC prognostic risk model in TCGA dataset using these identified prognostic genes. The model’s stability was confirmed in two independent verification sets (GSE14520 and GSE36376). The model had a good predictive power for the overall survival (OS) of HCC (Hazard Ratio=2.32, 95% Confidence Interval=1.76–3.05, p<0.001). Moreover, the risk score computed by the model did not depend on other clinical parameters. Finally, the applicability of the model was demonstrated through a nomogram (C-index=0.701). In this study, we established an autophagy-related risk model having a high prediction accuracy for OS in HCC. Our findings will contribute to the definition of prognosis and establishment of personalized therapy for HCC patients.

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Section: Discussionsupporting

confidence: 91%

Identification of an autophagy-related gene signature predicting overall survival for hepatocellular carcinoma

Guo

Lü

et al. 2021

Bioscience Reports

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“…For rs9904341 (c.-31G>C), the major G allele and GG genotype were associated with positive lymph nodes and higher TNM status in this study. This polymorphism is the most studied BIRC5 polymorphism [28] and the subject of several meta-analyses [29][30][31]. It is located in the 5 ′ UTR region of the BIRC5 gene and modifies the binding motif of the CDE/CHR repressor [27].…”

Section: Discussionmentioning

confidence: 99%

“…It is located in the 5 ′ UTR region of the BIRC5 gene and modifies the binding motif of the CDE/CHR repressor [27]. It has been associated with susceptibility (oral [15,32], esophageal [16,33], colorectal [17,34,35], lung [14], and urinary tract cancers [22,31,[36][37][38][39][40]), survival (colorectal [17] and lung cancers [41]), and age of onset (ovarian [19] and prostate cancers [42]). As in this study, an association was also found with stage and lymph node status (oral [43,44], esophageal [33], pancreatic [45], urinary [36,38,39], lung [46], and colorectal cancers [34]).…”

Section: Discussionmentioning

confidence: 99%

BIRC5 Gene Polymorphisms Are Associated with a Higher Stage of Local and Regional Disease in Oral and Oropharyngeal Squamous Cell Carcinomas

Mumlek,

Ozretić,

Sabol

et al. 2023

IJMS

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Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) are the most common types of cancers in the head and neck region (HNSCC). Despite very aggressive treatment modalities, the five-year survival rate has not changed for decades and is still around 60%. The search for potential specific biomarkers of aggressiveness or outcome indicators could be of great benefit in improving the treatment of these patients. One of the potential biomarkers is survivin, the protein product of the BIRC5 gene. In this study, we investigated the occurrence of BIRC5 gene polymorphisms in 48 patients with OSCC and OPSCC compared with healthy controls. A total of 18 polymorphisms were found, 11 of which occurred in HNSCC with a minor allele frequency (MAF) of more than 5%. Five polymorphisms (rs3764383, rs9904341, rs2071214, rs2239680, rs2661694) were significantly associated with tumor size, tumor stage, and advanced regional disease, but had no impact on survival.

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“…Moreover, studies provide support that paracrine IGF1/IGF1R signaling promotes colorectal cancer progression [ 26 , 27 ].Regulation of TFGBR3 contributes to the development of pancreatic ductal adenocarcinoma and metastasis of clear-cell renal cell carcinoma [28] .The expression of MASP-1 is down-regulated in the tumor samples compared to normal samples from GEO datasets. It's reported that MASP-1 serum levels are associated with worse prognostic in cervical cancer progression [29] .A meta-analysis reveals that several polymorphisms of BIRC5, a member of apoptosis inhibition gene family, might cause the different risk of urinary cancer [30] .…”

Section: Discussionmentioning

confidence: 99%

Survival prediction and response to immune checkpoint inhibitors: A prognostic immune signature for hepatocellular carcinoma

Zheng

2021

Translational Oncology

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Highlights As is known to us, this is the first immune-gene-related signature of HCC which was validated in various ways. This signature was linked to the mutation status, and we found the difference of mutation between two risk groups. We estimated the association among the signature, TMB and the survival and found the result contrary to previous studies.

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What is the impact of BIRC5 gene polymorphisms on urinary cancer susceptibility? Evidence from 9348 subjects

Cited by 5 publications

References 41 publications

Identification of an autophagy-related gene signature predicting overall survival for hepatocellular carcinoma

Identification of an autophagy-related gene signature predicting overall survival for hepatocellular carcinoma

BIRC5 Gene Polymorphisms Are Associated with a Higher Stage of Local and Regional Disease in Oral and Oropharyngeal Squamous Cell Carcinomas

Survival prediction and response to immune checkpoint inhibitors: A prognostic immune signature for hepatocellular carcinoma

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