What is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility?

Ozkan, Zehra Sema; Deveci, Derya; Kumbak, Banu; Şi̇mşek, Mehmet; Ilhan, Fulya; Sekercioglu, Samet; Sapmaz, Ekrem

doi:10.1016/j.jri.2013.11.002

Cited by 47 publications

(44 citation statements)

References 43 publications

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“…Serum levels of interleukin 6, 8 and tumor necrosis factor-α were described to be increased in patients with ectopic pregnancy [56], but some studies also showed decreased interleukin-8 levels [57]. Contradictory to our data is the finding of an increased ratio of TNF-α and IL-10 on infertile compared to fertile patients [61].…”

Section: Discussionsupporting

confidence: 58%

Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Bareksei¹,

Häfner²,

Pfeiffer³

et al. 2019

IJCEMS

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A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of invitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.

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Section: Discussionsupporting

confidence: 58%

Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Bareksei¹,

Häfner²,

Pfeiffer³

et al. 2019

IJCEMS

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show abstract

“…(Zuure et al, 2013) are located, and the anteroventral periventricular nucleus (AVPV) and surrounding medial preoptic area (mPOA). Estradiol acts on neurons within the AVPV during the period immediately preceding ovulation to induce a switch from negative to positive estrogenic feedback (Le et al, 1997;Smith et al, 2006), causing a surge of GnRH and consequently luteinizing hormone (LH) from the anterior pituitary gland, followed by ovulation (Homburg et al, 1976;Franz, 1988). Leptin may regulate estrous cyclicity and LH release in mice via mPOA neuronal nitric oxide-producing cells (Bellefontaine et al, 2014).…”

Section: Significance Statementmentioning

confidence: 99%

Deletion of Suppressor of Cytokine Signaling 3 from Forebrain Neurons Delays Infertility and Onset of Hypothalamic Leptin Resistance in Response to a High Caloric Diet

McEwen

Inglis

Quennell

et al. 2016

Journal of Neuroscience

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Obesity is commonly associated with infertility in humans and other animals. Treatments for human infertility show a decreased success rate with increasing body mass index. A hallmark of obesity is an increase in circulating leptin levels; despite this, the brain responds as if there were low levels of leptin, leading to increased appetite and suppressed fertility. Here we show that leptin resistant infertility is caused in part by the leptin signaling molecule SOCS3. Deletion of SOCS3 from brain neurons delays the onset of diet-induced infertility.

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“…In a recent and well-thought article, it has been shown that NK cell-mediated inhibition of Th17 is lost in patients with recurrent spontaneous abortion, leading to a Th17 response and inflammation (49). Elevated IL-17 levels have also been observed in plasma of patients suffering from unexplained infertility (56). Altogether, those results indicate that Th17 cells seem to exert a negative impact upon fertility.…”

Section: Cd4 T Cells Important For Pregnancymentioning

confidence: 99%

The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy

et al. 2014

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Acceptance of the fetal semi-allograft by the mother’s immune system has become the focus of intensive research. CD4+ T cells are important actors in the establishment of pregnancy. Th1/Th2 paradigm has been expanded to include CD4+ regulatory T (Treg) and T helper 17 (Th17) cells. Pregnancy hormones exert very significant modulatory properties on the maternal immune system. In this review, we describe mechanisms by which the endocrine milieu modulates CD4 T cell polarization during pregnancy. We first focused on Treg and Th17 cells and on their importance for pregnancy. Secondly, we review the effects of pregnancy hormones [progesterone (P4) and estradiol (E2)] on immune cells previously described, with a particular attention to human chorionic gonadotropin (hCG). The importance of Treg cells for pregnancy is evidenced. They are recruited before implantation and are essential for pregnancy maintenance. Decreased number or less efficient Treg cells are implicated in fertility disorders. As for Th17 cells, the few available studies suggest that they have a negative impact on fertility. Th17 frequency is increased in infertile patients. With the combination of its pro-effects on Th2 and Treg cells and anti-effects on Th1 and Th17 cells, P4 contributes to establishment of a favorable environment for pregnancy. E2 effects are more dependent on the context but it seems that E2 promotes Treg and Th2 cells while it inhibits Th1 cells. hCG positively influences activities of Treg and uterine natural killer cells. This embryo signal is an essential actor for the success of pregnancy, both as the endocrine factor regulating P4 secretion by the ovarian corpus luteum, but also as a paracrine agent during implantation as well as an angiogenic and immunologic mediator during the course of gestation. Luteinizing hormone (LH) immune properties begin to be studied but its positive impact on Treg cells suggests that LH could be a considerable immunomodulator in the mouse.

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What is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility?

Cited by 47 publications

References 43 publications

Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Deletion of Suppressor of Cytokine Signaling 3 from Forebrain Neurons Delays Infertility and Onset of Hypothalamic Leptin Resistance in Response to a High Caloric Diet

The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy

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