What is the impact of sex hormones on the pathogenesis of rheumatoid arthritis?

Raine, Charles; Giles, Ian

doi:10.3389/fmed.2022.909879

Cited by 19 publications

(13 citation statements)

References 101 publications

(63 reference statements)

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“…[ 6 ] Despite menopausal arthralgia being another frequent symptom,[ 7 8 ] it is relatively less recognised compared to hot flashes and psychiatric symptoms in Japan. Because the onset of menopausal arthralgia coincides with the age of susceptibility to rheumatic diseases such as rheumatoid arthritis[ 9 ] and patients visiting orthopaedic and rheumatology outpatient clinics may not be considered in need of medical care because of the absence of inflammatory or other pathological findings on diagnostic imaging or blood tests. Additionally, there is no established treatment for menopausal arthralgia, although some reports indicate the usefulness of HRT.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have suggested that menopausal arthralgia is caused by a decrease in oestrogen level[ 8 9 22 ]; unkeito has been reported to regulate the secretion of female hormones, thereby alleviating arthralgia. [ 24 25 ] Unkeito suppresses bone loss and promotes osteoclast apoptosis and may reduce arthralgia by regulating the secretion of female hormones and preventing bone fragility.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of combination therapy with unkeito and boiogito for menopausal arthralgia: A retrospective observational study

Nogami,

Taniguchi,

Miyatake

et al. 2024

Journal of Family Medicine and Primary Care

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Context: Arthralgia affects menopausal patients. Aim: Here, we report a retrospective observational study evaluating the therapeutic efficacy of a combination of unkeito and boiogito for menopausal arthralgia. Settings and Design: Patients treated with a combination of unkeito and boiogito for menopausal arthralgia between April 2020 and October 2022 at three Japanese Kampo outpatient clinics were retrospectively examined. Treatment effectiveness was determined based on the patient’s description of pain. Adverse events associated with this treatment regimen were also recorded. The study design was approved by the Tokai University Ethics Committee (Approval number: 22R196). Methods and Material: This study was conducted by retrospectively analysing the medical records of patients who attended the three medical facilities. All patients received Kampo medicines based on traditional medical diagnoses. Outpatients with a diagnosis of menopausal arthralgia were selected, and information on those who were treated with a combination of unkeito and boiogito was collected. Statistical Analysis: The age, height, and weight of all patients are represented as the mean ± standard deviation. Statistical analyses were not performed in this study as there was no comparison group. Results: During the study period, nine patients with menopausal arthralgia received the unkeito and boiogito combination. Four patients showed a “significant” response to the combination treatment, four showed an “effective” response, and one patient showed an “ineffective” response. One patient reported headache as an adverse event. Conclusion: The combination of unkeito and boiogito may be effective in the treatment of menopausal arthralgia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of combination therapy with unkeito and boiogito for menopausal arthralgia: A retrospective observational study

Nogami,

Taniguchi,

Miyatake

et al. 2024

Journal of Family Medicine and Primary Care

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“…Female dominancy of RA and its lower incidence in men indicate that there is a hormonal effect on this disease 14 . The incidence in men rose steeply with age, whereas the incidence in women fell in the very elderly.…”

Section: Discussionmentioning

confidence: 99%

Temporomandibular joint involvement in elderly onset and young onset rheumatoid arthritis patients

Ilhanli,

Ilhanli

2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: There are studies showing clinical and laboratory differences between elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis. Temporomandibular joint involvement in rheumatoid arthritis is not rare. In this study, we aimed to examine the temporomandibular joint involvement and magnetic resonance imaging findings in elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis patients. METHODS: A total of 87 rheumatoid arthritis patients were investigated retrospectively. The onset ≥60 years was considered elderly-onset rheumatoid arthritis. Erosion, flattening, and resorption of the condyle, narrowing of the joint space, joint effusion, synovial hypertrophy, and synovitis were interpreted as temporomandibular joint involvement with magnetic resonance imaging. Patients’ age, gender, rheumatoid factor, and anti-cyclic citrullinated peptide positivity, extra-articular findings, medical treatment, and disease activity score were noted. RESULTS: A total of 15 (17.2%) patients had elderly-onset rheumatoid arthritis. Temporomandibular joint involvement was detected in 67 (77%) patients; 9 (60%) of them were in the elderly-onset rheumatoid arthritis group (n=15) and 58 (80.6%) of them were in the young-onset rheumatoid arthritis group (n=72). Patients with temporomandibular joint involvement were significantly higher than those without temporomandibular joint involvement in both the elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis groups (p<0.001). No significant difference was found between elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis for the temporomandibular joint involvement (p=0.100). In the young-onset rheumatoid arthritis group, rheumatoid factor positivity and anti-cyclic citrullinated peptide positivity were more frequent in the patients with temporomandibular joint involvement (p=0.011, p=0.024). A comparison of the elderly-onset rheumatoid arthritis and young-onset rheumatoid arthritis patients showed no significant difference in the magnetic resonance imaging findings except for the resorption of the condyle. CONCLUSION: According to our findings, elderly-onset rheumatoid arthritis is not much different from young-onset rheumatoid arthritis in terms of temporomandibular joint involvement, magnetic resonance imaging findings, and clinical and laboratory features.

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“…RA is around three times more common in females than males and has a peak age of onset around the time of menopause in women, but occurs towards later life in men ( 6 ). The onset of RA is associated with the post-menopausal and postpartum periods, suggesting links with falling levels of female sex hormones ( 6 , 10 , 201 ). Of note, men with RA have lower androgen concentrations and higher estrogen levels than controls ( 149 ).…”

Section: Sex Bias In Lymphocytes In Autoimmune Diseasesmentioning

confidence: 99%

Sex bias in lymphocytes: Implications for autoimmune diseases

Dodd

Menon

2022

Front. Immunol.

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Autoimmune diseases are characterized by a significant sex dimorphism, with women showing increased susceptibility to disease. This is, at least in part, due to sex-dependent differences in the immune system that are influenced by the complex interplay between sex hormones and sex chromosomes, with contribution from sociological factors, diet and gut microbiota. Sex differences are evident in the number and function of lymphocyte populations. Women mount a stronger pro-inflammatory response than males, with increased lymphocyte proliferation, activation and pro-inflammatory cytokine production, whereas men display expanded regulatory cell subsets. Ageing alters the immune landscape of men and women in differing ways, resulting in changes in autoimmune disease susceptibility. Here we review the current literature on sex differences in lymphocyte function, the factors that influence this, and the implications for autoimmune disease. We propose that improved understanding of sex bias in lymphocyte function can provide sex-specific tailoring of treatment strategies for better management of autoimmune diseases.

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What is the impact of sex hormones on the pathogenesis of rheumatoid arthritis?

Cited by 19 publications

References 101 publications

Efficacy of combination therapy with unkeito and boiogito for menopausal arthralgia: A retrospective observational study

Efficacy of combination therapy with unkeito and boiogito for menopausal arthralgia: A retrospective observational study

Temporomandibular joint involvement in elderly onset and young onset rheumatoid arthritis patients

Sex bias in lymphocytes: Implications for autoimmune diseases

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