What is the impact of low testosterone levels on the anatomical and behavioral repertoire of long-term enriched housing of male mice?

Lima, Fernanda Barbosa; Oliveira, E S

doi:10.1016/j.beproc.2014.09.025

Cited by 11 publications

(4 citation statements)

References 38 publications

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“…It is possible that previous studies have failed to provide sufficient quantities of enrichment to mitigate competition [ 140 ]. While there are many examples of structural enrichment resulting in increased aggression among males (e.g., [ 141 , 142 ]), there are also many cases of successful enrichment use (involving a range of genetic strains and enrichment strategies) [ 143 , 144 , 145 , 146 , 147 ]. In one example, male mice housed with hemp ropes hanging from the cage lid demonstrated more aggression when frequently tail-handled by experimenters; when handling was reduced, mice housed with hemp ropes showed no differences in aggression compared to the conventionally housed control group [ 145 ].…”

Section: Resultsmentioning

confidence: 99%

Environmental Enrichment for Rats and Mice Housed in Laboratories: A Metareview

Ratuski

Weary

2022

Animals

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Environmental enrichment has been widely studied in rodents, but there is no consensus on what enrichment should look like or what it should achieve. Inconsistent use of the term “enrichment” creates challenges in drawing conclusions about the quality of an environment, which may slow housing improvements for laboratory animals. Many review articles have addressed environmental enrichment for laboratory rats and mice (Rattus norvegicus and Mus musculus). We conducted a metareview of 29 review articles to assess how enrichment has been defined and what are commonly described as its goals or requirements. Recommendations from each article were summarised to illustrate the conditions generally considered suitable for laboratory rodents. While there is no consensus on alternative terminology, many articles acknowledged that the blanket use of the terms “enriched” and “enrichment” should be avoided. Environmental enrichment was most often conceptualised as a method to increase natural behaviour and improve animal welfare. Authors also commonly outlined perceived risks and requirements of environmental enrichment. We discuss these perceptions, make suggestions for future research, and advocate for the adoption of more specific and value-neutral terminology.

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Section: Resultsmentioning

confidence: 99%

Environmental Enrichment for Rats and Mice Housed in Laboratories: A Metareview

Ratuski

Weary

2022

Animals

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“…Inside each EE cage, and during 15 consecutive days, mice were provided with colorful plastic devices made of LEGO® building bricks, hard paper, cotton nesting material, plastic tube (15 cm long and 3 cm in diameter), and plastic dolls exchanged every week. These objects have been previously used as enriched conditions for mice leading to significant molecular and behavioral differences in laboratory animals (Grinan-Ferre et al 2018;Hess et al 2008;Lima and Spinelli de Oliveira 2014;Lopez and Laber 2015).…”

Section: Standard and Environment Enrichmentmentioning

confidence: 99%

Environmental enrichment decreases chronic psychosocial stress-impaired extinction and reinstatement of ethanol conditioned place preference in C57BL/6 male mice

Bahí

Dreyer

2019

Psychopharmacology

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Rationale During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alcoholism. On the other hand, environmental enrich-ment (EE) has a neuroprotective role and prevents the development of excessive ethanol intake in rodents. However, studies showing the role of EE in chronic psychosocial stress-impaired ethanol-conditioned rewards are nonexistent. Aim The purpose of the current study is to explore the potential protective role of EE on extinction and reinstatement of ethanolconditioned place preference (EtOH-CPP) following chronic psychosocial stress. Methods In the first experiment and after the EtOH-CPP test, the mice were subjected to 15 days of chronic stress, then housed in a standard (SE) or enriched environment (EE) while EtOH-CPP extinction was achieved by repeated exposure to the CPP chambers without ethanol injection. In the second experiment and after the EtOH-CPP test, extinction was achieved as described above. Mice were then exposed to chronic stress for 2 weeks before being housed in a SE or EE. EtOH-CPP reinstatement was induced by a single exposure to the conditioning chambers. Results As expected, stress exposure increased anxiety-like behavior and reduced weight gain. More importantly, we found that EE significantly shortened chronic stress-delayed extinction and decreased the reinstatement of EtOH-CPP. Conclusion These results support the hypothesis that EE reduces the impact of alcohol-associated environmental stimuli, and hence it may be a general intervention for reducing cue-elicited craving and relapse in humans.

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“…Enriched housing represents greater complexity and novelty of the environment, with groups of different sizes (usually 8-10 animals per cage, although some studies include up to 20) sharing a cage for several weeks or months (Nithianantharajah & Hannan, 2009;Sale, 2018;Sale et al, 2014). The need to evaluate how agonistic interactions and dominant-subordinate relationships in male rodents may change as a consequence of being housed in EE has been highlighted in different reports (Cao et al, 2017;Giles et al, 2018;Hutchinson et al, 2012;Lima & Spinelli de Oliveira, 2014;Van Loo et al, 2003). Some studies have suggested that the presence of novel objects in the cage and the complexity of the environment enhance aggressive behaviors due to the competition for resources or physical proximity between animals (Abou-Ismail, 2011;Giles et al, 2018;McQuaid et al, 2013;McQuaid et al, 2018), the elimination of territorial odor-marking or failure to control the environment (Kaliste et al, 2006;Van Loo et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Inconsistency in the results obtained could be related to methodological differences between different laboratories. Furthermore, we must take into account that the effect of housing conditions on aggressive interactions may have a bearing on the welfare of animals (Giles et al, 2018;Kimura et al, 2017;Lima & Spinelli de Oliveira, 2014;Toth et al, 2011) that makes it an issue of great relevance to Laboratory Animal Science (André et al, 2018;Bailoo et al, 2018;Baumans & Van Loo, 2013;Macrì et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Behavioral impact of experience based on environmental enrichment: Influence of age and duration of exposure in male NMRI mice

Mesa-Gresa

Ramos-Campos

Redolat

2021

Developmental Psychobiology

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Prior studies have suggested that short periods of exposure to environmental enrichment (EE) in rodents induce physiological and behavioral effects. In the present study, our aim was to evaluate if the impact of experiences based on EE could be modulated by the age of onset and the developmental period of exposure. NMRI male mice (n = 64) were exposed to EE or standard environment (SE) and behavioral changes (anxiety, exploration, memory and social interaction) were evaluated.

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What is the impact of low testosterone levels on the anatomical and behavioral repertoire of long-term enriched housing of male mice?

Cited by 11 publications

References 38 publications

Environmental Enrichment for Rats and Mice Housed in Laboratories: A Metareview

Environmental Enrichment for Rats and Mice Housed in Laboratories: A Metareview

Environmental enrichment decreases chronic psychosocial stress-impaired extinction and reinstatement of ethanol conditioned place preference in C57BL/6 male mice

Behavioral impact of experience based on environmental enrichment: Influence of age and duration of exposure in male NMRI mice

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