What is the impact of thyroidectomy on autoimmune features associated with Hashimoto's thyroiditis?—Institutional experience

Panchangam, RB; Kota, SK; Mayilvaganan, Sabaretnam; Kuravi, BG

doi:10.4103/njcp.njcp_426_20

Cited by 3 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, antibodies from GD patients can induce cytokines in RA patient fibroblasts and vice versa [ 60 ]. Panchangam et al [ 61 ] hypothesized that ATA may target epitopes outside the thyroid, making other organs vulnerable to autoimmune attack. They conducted a retrospective study of 61 HT patients who underwent total thyroidectomy.…”

Section: Effect Of Aitd On Ra Disease Activitymentioning

confidence: 99%

“…They conducted a retrospective study of 61 HT patients who underwent total thyroidectomy. They found that post-thyroidectomy TPOAb levels decreased from a mean of 339 to 59 IU/L, and there were major improvements in patients’ associated autoimmune features including RA [ 61 ]. These common and overlapping immune activation pathways may help to explain the reported exacerbation of disease activity in patients with an RA and AITD overlap [ 62 , 63 ].…”

Section: Effect Of Aitd On Ra Disease Activitymentioning

confidence: 99%

See 1 more Smart Citation

Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

Lichtiger,

Fadaei,

Tagoe

2024

Clin Rheumatol

View full text Add to dashboard Cite

Autoimmune thyroid disease (AITD) is the most prevalent autoimmune disease. It shares multiple genetic, clinical, and serologic characteristics with rheumatoid arthritis (RA). Although frequently described as a classic form of single-organ autoimmunity, the AITD disease burden in a subset of patients extends well beyond the thyroid gland. This review explores the complex interaction between the two diseases and the clinical consequences when they overlap. Beyond the well-known effects of AITD on thyroid function in RA, there is mounting evidence of the association of both conditions impacting the presentation and outcomes of diabetes, metabolic syndrome, and cardiovascular disease. An increasing number of studies suggest that there are negative effects of AITD on RA disease activity both in the presence and in the absence of thyroid dysfunction. Recent evidence suggests that AITD may not only worsen the cumulative damage of RA through higher disease activity but may also worsen secondary osteoarthritis changes. Less well-known is the significant association between AITD and chronic widespread pain syndromes including fibromyalgia. Importantly, the presence of fibromyalgia, which is increased in RA patients, appears to be further increased when it overlaps with AITD. Lastly, we probe the possible influence of AITD interacting with RA on fertility and clinical depression. Key Points• Autoimmune thyroid disease is the most common autoimmune disease and is frequently associated with rheumatoid arthritis.• Autoimmune thyroid disease can present with osteoarthritis, inflammatory arthritis, and chronic widespread pain syndromes.• The co-occurrence of autoimmune thyroid disease and rheumatoid arthritis may worsen disease activity and exacerbate other disease manifestations including cardiovascular disease, fertility, and depression.• The overlap of rheumatoid arthritis with autoimmune thyroid disease needs further research and should be sought in general clinical practice.

show abstract

Section: Effect Of Aitd On Ra Disease Activitymentioning

confidence: 99%

Section: Effect Of Aitd On Ra Disease Activitymentioning

confidence: 99%

Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

Lichtiger,

Fadaei,

Tagoe

2024

Clin Rheumatol

View full text Add to dashboard Cite

show abstract

Total Thyroidectomy in Hashimoto Thyroiditis: are We in the Right Path?

Sarathi

Dhananjaya

2022

Indian J Surg

View full text Add to dashboard Cite

Outcomes of thyroidectomy in symptomatic, euthyroid Hashimoto's patients: a case control study

Serrao‐Brown,

Saadi,

Wong

et al. 2024

ANZ Journal of Surgery

View full text Add to dashboard Cite

BackgroundHashimoto's thyroiditis (HT) is managed with thyroid hormone replacement to maintain a euthyroid state. A subset of patients have refractory symptoms, which improve with thyroidectomy (TT). There remains a reluctance to proceed with surgery due to perceptions of complications, and limited data availability regarding improvements in quality of life (QoL). This retrospective case control study aims to analyse the outcomes and QoL scores for symptomatic euthyroid HT patients who underwent TT.MethodsThirty euthyroid patients who underwent TT for the management of HT between 2017 and 2022 were identified. An age‐matched control group of patients who underwent TT for symptomatic multinodular goitre (MNG) were randomly selected. Demographics, biochemistry, histology, outcomes, and pre‐ and post‐operative SF‐36 and ThyPRO‐39 scores were compared between groups.ResultsThere were no surgical complications in the HT group, whilst two MNG patients had complications. There was a similar rate of parathyroid auto‐transplantation in both groups, more glands were transplanted in the HT group. There was a significant difference in pre‐ and post‐operative QoL scores for both groups. Comparison revealed a significant improvement in hyperthyroid symptoms, social life and daily life scores in the HT group. There was a significant difference in pre‐ and post‐operative anti‐TPO, anti‐TG and TSH levels in the HT group.ConclusionPatients with symptomatic Hashimoto's thyroiditis, despite being euthyroid, may benefit from total thyroidectomy however this remains under‐utilized. This study demonstrated that thyroidectomy was associated with an improvement in validated post‐operative quality of life scores and was not associated with increased complication rates for appropriately selected patients.

show abstract

What is the impact of thyroidectomy on autoimmune features associated with Hashimoto's thyroiditis?—Institutional experience

Cited by 3 publications

References 1 publication

Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

Autoimmune thyroid disease and rheumatoid arthritis: where the twain meet

Total Thyroidectomy in Hashimoto Thyroiditis: are We in the Right Path?

Outcomes of thyroidectomy in symptomatic, euthyroid Hashimoto's patients: a case control study

Contact Info

Product

Resources

About