What is the evidence that there is antimicrobial resistance associated with the use of topical antimicrobial preparations?

Blackburn, Joanna; Ousey, Karen; Patton, Declan; Moore, Zena; O’Connor, Tom

doi:10.33235/wpr.31.1.40-48

Cited by 2 publications

(1 citation statement)

References 38 publications

(106 reference statements)

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“…28 Choosing the right antiseptic for the patient is crucial to avoid causing unnecessary problems, including additional skin irritation. 32 Consistently, Blackburn et al 34 explored the effects of using topical antimicrobials on AMR and found that there was very limited evidence to prove efficacy, with most clinical evidence focusing on exploring the effectiveness of topical antimicrobials on infection and subsequent wound healing. The authors suggested that understanding the contribution of topical antimicrobials in AMR remains an important issue that is yet to be fully investigated.…”

Section: Ams and Antisepticsmentioning

confidence: 99%

Skin integrity, antimicrobial stewardship and infection control: a critical review of current best practice

Blackburn,

Kopecki,

Ousey

2024

WPR

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Skin integrity' refers to intact, unbroken, and healthy skin. Disruption of skin integrity can be caused by intrinsic and extrinsic factors including altered nutritional status, vascular disease, diabetes, and tissue injury, and this is often associated with development of localised clinical infection. Skin health and hygiene is important for preventing wounds and development of localised clinical infection or sepsis. Clinical wound infection is an increasing problem in healthcare, with the potential for increasing the burden of antimicrobial resistance (AMR), if antimicrobials are overused to treat wound infection.In this review we discuss skin integrity and wound infection prevention and outline the guiding principles of antimicrobial resistance and antimicrobial stewardship for infection control. Additionally, we provide a critical review of current best practice, highlighting the pathway to guide management of patients at risk of infection development, and discuss the latest research progress on antimicrobial resistance and skin integrity.

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Section: Ams and Antisepticsmentioning

confidence: 99%

Skin integrity, antimicrobial stewardship and infection control: a critical review of current best practice

Blackburn,

Kopecki,

Ousey

2024

WPR

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Liposome drug delivery in combating the widespread topical antibiotic resistance: a narrative review

Rizkita,

Putri,

Farid

et al. 2024

Beni-Suef Univ J Basic Appl Sci

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Background The increasing trend of antibiotic resistance has posed challenges for scientists, especially in developing better drug formulations. The discovery of new antibiotics could take years. Therefore, the management of an ideal drug delivery system has become a primary focus nowadays. Main body of abstract Almost all skin diseases could be treated with the administration of topical drugs, especially infectious skin diseases. The increasing cases of antimicrobial resistance require innovative strategies and actions. In dermatokinetics, achieving optimal drug concentrations in the deepest layers of skin tissue is a significant challenge. Human skin has remarkably complex characteristics, presenting a major obstacle in efficiently maintaining drug efficacy. Nanocarriers are an important part of nanomedicine which provide excellent drug penetration through various drug delivery systems. Lipid-based nanovesicles, such as liposome, are the oldest and most potential nanovesicles for such a purpose. Several studies have shown the efficacy of liposome-contained antibiotics and offered the lowest microbial inhibition concentration (MIC). It is suggested that liposome also delivers greater drug accumulation compared to blank drugs. Short conclusion Liposome is a flexible lipid-based drug delivery that enhances drug permeation through skin tissue by mimicking the lipid bilayer system of the organ. It is non-toxic, less immunogenic, and easily degraded by enzyme. The incorporation of liposome into antibiotics may reduce the inefficient drug dosage since the encapsulation will protect the active compounds prior to being released from the vehicle. Thus, the lowest MIC and less clinical side effects will be obtained. Graphical abstract

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What is the evidence that there is antimicrobial resistance associated with the use of topical antimicrobial preparations?

Cited by 2 publications

References 38 publications

Skin integrity, antimicrobial stewardship and infection control: a critical review of current best practice

Skin integrity, antimicrobial stewardship and infection control: a critical review of current best practice

Liposome drug delivery in combating the widespread topical antibiotic resistance: a narrative review

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