2017
DOI: 10.1186/s40478-017-0488-7
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What is the evidence that tau pathology spreads through prion-like propagation?

Abstract: Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas. This propagation could occur through a “prion-like” mechanism involving transfer of abnormal tau seeds from a “donor cell” to a “recipient cell” and recruitment of normal tau in the latter to generate new tau seeds. This review critically appraises the evidence that the spread of tau pathology occurs via such a “prio… Show more

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Cited by 291 publications
(286 citation statements)
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References 149 publications
(214 reference statements)
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“…Although we recognize that there are many differences between AD and prion diseases, there are also striking similarities. The accumulation and clearance of the misfolded protein, glial responses, and the patterns of neurodegeneration strongly imply that common mechanisms may operate (13,23,24). Thus, the study of these diseases in parallel has the potential to more rapidly advance knowledge.…”
mentioning
confidence: 99%
“…Although we recognize that there are many differences between AD and prion diseases, there are also striking similarities. The accumulation and clearance of the misfolded protein, glial responses, and the patterns of neurodegeneration strongly imply that common mechanisms may operate (13,23,24). Thus, the study of these diseases in parallel has the potential to more rapidly advance knowledge.…”
mentioning
confidence: 99%
“…However, it has recently become clear that tau is released by neurons in both health and disease . This suggests that tau, apart from interacting with microtubules, has other functions as well . Finally, together with phosphorylation, additional posttranslational modifications, including acetylation and truncation, are thought to participate in the disease process and have been studied in recent years …”
Section: Psp: Milestones Of the Recent 10 Yearsmentioning
confidence: 99%
“…50 It is still unknown which are the exact tau forms that are responsible for the propagation of pathology and for neurotoxicity. 51 Nevertheless, the prion-like model for tau spread requires that pathological tau conformations can move from cell to cell. 51 Various mechanisms have been described by which tau aggregates can be released or taken up by cells.…”
Section: Elucidating the Genetic Aspects Of Pspmentioning
confidence: 99%
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