What Is the Burden of Chronic Cough for Families?

Marchant, Julie M.; Newcombe, Peter; Juniper, Elizabeth F.; Sheffield, Jeannie K.; Stathis, Stephen; Chang, Anne B.

doi:10.1378/chest.07-2236

Cited by 194 publications

(213 citation statements)

References 29 publications

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“…A UK postal survey found that the majority of people reporting cough were distressed, angry, anxious and depressed, and 64% felt the cough interfered with their social and family life [97,98]. However, the relationship between health status and cough reflex sensitivity, as defined by inhalational challenge, is weak.…”

Section: Cough In Other Diseasesmentioning

confidence: 99%

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

et al. 2014

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In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions.There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough.The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area. @ERSpublications Cough hypersensitivity syndrome was clearly endorsed by opinion leaders as a valid and useful concept

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Section: Cough In Other Diseasesmentioning

confidence: 99%

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

et al. 2014

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“…Finally, atopy did not influence the change in FeNO levels post-exercise. Cough with exercise or post-exercise is not rare and is sometimes used as a marker of asthma in children and adults (2,3). Delineating whether exercise-associated cough really reflects asthma would be useful in clinical practice, particularly in children.…”

Section: Discussionmentioning

confidence: 99%

“…Cough is one of the most common symptoms presenting to doctors and when present in children, is associated with impaired quality of life and burden to parents (1). Cough associated with exercise is often considered a symptom of asthma.…”

Section: Introductionmentioning

confidence: 99%

Cough and exhaled nitric oxide levels: what happens with exercise?

Petsky¹,

Kynaston²,

McElrea³

et al. 2013

Paediatric Respiratory Reviews

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Cough associated with exertion is often used as a surrogate marker of asthma. However, to date there are no studies that have objectively measured cough in association with exercise in children. Our primary aim was to examine whether children with a pre-existing cough have an increase in cough frequency during and post-exercise. We hypothesized that children with any coughing illness will have an increase in cough frequency postexercise regardless of the presence of exercise-induced broncho-constriction (EIB) or atopy. In addition, we hypothesized that Fractional exhaled nitric oxide (FeNO) levels decreases post-exercise regardless of the presence of EIB or atopy. Children with chronic cough and a control group without cough undertook an exercise challenge, FeNO measurements and a skin prick test, and wore a 24-h voice recorder to objectively measure cough frequency. The association between recorded cough frequency, exercise, atopy, and presence of EIB was tested. We also determined if the change in FeNO post exercise related to atopy or EIB. Of the 50 children recruited (35 with cough, 15 control), 7 had EIB. Children with cough had a significant increase in cough counts (median 7.0, inter-quartile ranges, 0.5, 24.5) compared to controls (2.0, IQR 0, 5.0, p = 0.028) post-exercise. Presence of atopy or EIB did not influence cough frequency. FeNO level was significantly lower post-exercise in both groups but the change was not influenced by atopy or EIB. Cough post-exertion is likely a generic response in children with a current cough. FeNO level decreases post-exercise irrespective of the presence of atopy or EIB. A larger study is necessary confirm or refute our findings.

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“…In an Australian multi-centre study, 41 % of 346 children referred with chronic wet cough were diagnosed after a thorough examination as having protracted bacterial bronchitis (7). A large proportion of the children who were given the diagnosis have presented to primary care repeatedly and received various types of treatment, including treatment for possible asthma (7,8,12).…”

Section: Epidemiologymentioning

confidence: 99%