What is the best predictor of the severity of ABO‐haemolytic disease of the newborn?

Brouwers, Haa; Ertbruggen, Ingrid van; Alsbach, G. P. J.; Leeuwen, Esther van; Overbeeke, Mam; Schaasberg, W.; Heiden, Colin van der; Jw, Stoop; Engelfriet, C. P.

doi:10.1016/0020-7292(89)90754-6

Cited by 9 publications

(14 citation statements)

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“…In an earlier published study the sensitivity and specificity were lower at 53 and 73%, respectively 8 …”

Section: Discussionmentioning

confidence: 74%

Review of positive direct antiglobulin tests found on cord blood sampling

Dinesh¹

2005

J Paediatrics Child Health

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The positive predictive value of a positive DAT for HDN is 23%. The sensitivity was estimated to be 86%. Ten babies required readmission for phototherapy, two of these were DAT-positive. Jaundice, rather than the positive DAT, was the first alert in the majority of cases of HDN requiring phototherapy. Recommendations for testing are discussed but remain controversial in practice. Assessment for hyperbilirubinaemia in all infants early in life is fundamental.

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“…In an earlier published study the sensitivity and specificity were lower at 53 and 73%, respectively 8 …”

Section: Discussionmentioning

confidence: 74%

Review of positive direct antiglobulin tests found on cord blood sampling

Dinesh¹

2005

J Paediatrics Child Health

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“…To date, there is no explanation for the latter finding, but low anti-A in B and low anti-B in A may provide an advantage to women with these blood groups during ABO incompatible pregnancies, because only IgG are transferred through the placenta, exposing the child to the risk of haemolytic disease. This view is supported by the clinical finding, that only newborns of blood group O mothers develop haemolytic disease after ABOincompatible pregnancies (Brouwers et al, 1988). The apparent lack of antibody class switch in blood group A and B individuals may represent an interesting in vivo model to study the development of the natural Ab repertoire.…”

Section: Discussionmentioning

confidence: 87%

Isotype‐specific detection of ABO blood group antibodies using a novel flow cytometric method

Stüssi

Huggel

Lutz³

et al. 2005

Br J Haematol

108

103

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SummarySeveral methods to detect anti-A/B antibodies based on haemagglutination and haemolysis have been described. These methods measure predominantly anti-A/B immunoglobulin (Ig)M, whereas anti-A/B IgG and IgG subclasses are less well examined. We established a flow cytometry method (ABOfluorescence-activated cell sorting; ABO-FACS) to quantify binding of anti-A/B IgM, IgG and IgG subclasses to human A or B red blood cells. Anti-A/B IgM were present in the majority of 120 blood donors, as expected from blood group typing. The sensitivity and specificity of anti-A/B IgM to predict the blood group was 93% and 96% respectively. Anti-A/B IgG was found in 34/38 blood group O samples (89%). Anti-B IgG in blood group A or anti-A IgG in blood group B was present in 4/28 (14%) and 1/28 (4%) samples, respectively, and absent in 26 AB sera. IgG2 was the predominant IgG subclass. The correlation of anti-A/B IgM and IgG in the ABO-FACS with haemagglutination titres was 0AE870 and 0AE783, respectively (n ¼ 240; P < 0AE001) whereas the comparison of ABO-FACS with ABO-enzymelinked immunosorbent assay was less significant. In conclusion, ABO-FACS is a valid method to quantify anti-A/B IgM, IgG and IgG subclasses. It opens the possibility of isotype-specific monitoring of anti-A/B antibodies levels after ABO-incompatible solid organ and stem cell transplantation.

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“…A further reason for being unable to predict the incidence of ABO HDN is the very variable density of A and B antigen on fetal red cells. 4 There is an increased incidence and an increased severity of ABO HDN in certain populations: Arabs, Negroes, South-East Asians, and Latin-Americans, but again there is little predictive value from serological monitoring. However, it is essential that early postnatal diagnosis and management should be undertaken in children born to women from these particular ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

“…In this rare group of patients antenatal monitoring of anti-A and anti-B using an antibody dependent cell mediated cytotoxicity assay may be of use in predicting ABO HDN. 4 Once a pregnant woman's ABO group has been established by concordant results from two samples obtained on different occasions there is no further need for ABO testing. RhD typing Establishing a mother's RhD type is an essential part of early pregnancy testing.…”

Section: Introductionmentioning

confidence: 99%

ACP Broadsheet No 150. March 1997. Antenatal serological testing and prevention of haemolytic disease of the newborn.

Duguid¹

1997

J Clin Pathol

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What is the best predictor of the severity of ABO‐haemolytic disease of the newborn?

Cited by 9 publications

References 0 publications

Review of positive direct antiglobulin tests found on cord blood sampling

Review of positive direct antiglobulin tests found on cord blood sampling

Isotype‐specific detection of ABO blood group antibodies using a novel flow cytometric method

ACP Broadsheet No 150. March 1997. Antenatal serological testing and prevention of haemolytic disease of the newborn.

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