What Is the Benefit of Tranexamic Acid vs Reinfusion Drains in Total Joint Arthroplasty?

Springer, Bryan D.; Odum, Susan M.; Fehring, Thomas K.

doi:10.1016/j.arth.2015.08.006

Cited by 19 publications

(8 citation statements)

References 34 publications

(40 reference statements)

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“…In 50 of these 80 patients, the collected blood volume was below 100 ml and therefore too low to re-transfuse. Similar low rates of autologous blood transfusions due to low volumes were reported in another recently published study [29]. Further analysis shows that eight patients in the ABT group needed allogeneic blood transfusions.…”

Section: Discussionsupporting

confidence: 85%

“…They report no effect of ABT drains on the allogeneic blood transfusion rate, as transfusion rates of 5% were calculated for Redon and ABT drains. In a third randomized controlled study, Springer et al recently compared transfusion rates of 115 TKA patients between Redon drains, ABT drains and tranexamic acid [29]. Their indications to transfuse a patient were based on physical status rather than a set haemoglobin level.…”

Section: Discussionmentioning

confidence: 99%

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No benefit of autologous transfusion drains in total knee arthroplasty

Schnurr

Giannakopoulos

Arbab

et al. 2017

Knee Surg Sports Traumatol Arthrosc

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

No benefit of autologous transfusion drains in total knee arthroplasty

Schnurr

Giannakopoulos

Arbab

et al. 2017

Knee Surg Sports Traumatol Arthrosc

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“…In the recent decades, numerous studies have been published, assessing the efficiency of the tranexamic acid in reducing bleeding and the transfusion requirements in elective patients for total hip and knee arthroplasty. The results of these studies showed that the tranexamic acid proved to be efficient and safe in orthopaedic surger y [12][13][14][15][16][17][18]20,21,[23][24][25][26]. The two cases of endoprosthesis carried out in our service of orthopaedics have confirmed this hypothesis also in the case of the haemophilic patients, who were administered in the hemostatic protocol tranexamic acid in association with the substitutive factor of coagulation.…”

Section: Resultsmentioning

confidence: 86%

Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia

Bădulescu¹,

Tudor²,

Friedl³

et al. 2017

Rev. Chim.

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Haemophilia is an inherited bleeding disorder (gonosomala recessive, related to chromosome X, with transmission from carrying women to male descendents) characterised from the clinic point of view by important bleeding, secondary to some minimum and biologic traumas by deficiency of trombo-plastino-formation, consecutive to either a deficit of factor VIII (haemophilia A), or the factor IX (haemophilia B). The most characteristic manifestation of hemophilia is intra-articular � hemarthrosis. Its repetitive character leads to irreversible lesions of the articular structures, inducing lesions of the synovium with degenerative effects over the articular cartilage and destructive effects for the subchondral bone tissue. In time, these lesions require orthopaedic surgery to improve the locomotor activity. Managing an efficient hemostasis is vital during surgery, due to high risk of bleeding triggered by coagulopathy and surgery. Numerous studies carried out underlined the efficiency of the tranexamic acid (TXA) in reducing bleeding, in different surgery branches, by inhibiting the enzymatic degradation of fibrin. In orthopaedic surgery, the tranexamic acid is frequently used in case of hip and knee arthroplasties, reducing the bleeding and blood transfusion necessary to the treatment of posthaemorrhagic anemia. This paper wants to assess the efficiency of the tranexamic acid in realization of hemostasis to another category of patients, haemophiliac patients with indication of total hip and knee endoprosthesis.

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“…Tranexamic acid (TXA) is proved as a safe and cost-effective anti-fibrinolytic agent that inhibits activation of plasminogen to plasmin leading to a decrease in fibrinolytic activity and stabilizing clotting 8,9 . Tranexamic acid has gained significant popularity in total joint replacements given its potential benefits in terms of decreasing intraoperative blood loss and need for blood transfusion 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the efficacy of intra-articular tranexamic acid in patients with hypertension undergoing simultaneous bilateral total knee arthroplasty

Cobden

Çamurcu

Üçpunar

et al. 2018

Cumhuriyet Medical Journal

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The relationship between hypertension (HT) and increased perioperative transfusion rate in patients who underwent total knee arthroplasty (TKA) was previously investigated in the literature. This phenomenon may also increase the need for blood transfusion in patients who underwent bilateral simultaneous TKA despite using tranexamic acid (TXA). The main purpose of this study was to evaluate the decrease in hemoglobin levels and need for blood transfusion in patients with the diagnosis of HT who underwent bilateral simultaneous TKA after intra-articular (IA) administration of TXA in comparison to those who did not receive TXA. Method: One hundred and ninety-one patients with the diagnosis of HT who underwent bilateral simultaneous TKA and fulfilled the criteria, were evaluated in this retrospective study. Patients were grouped as TXA group (individuals who received IA TXA) and control group (did not receive TXA). Primary outcome measures were decrease in hemoglobin levels and number of blood units transfused. Results: Both groups were similar in age, gender, body mass index and American Society of Anesthesiologist (ASA) score and no statistically significant differences were observed. There was also no statistically significant difference between groups in terms of decrease in hemoglobin levels (P=0.844) and number of blood units transfused (P=0.095). Conclusions: According to our results, in patients with the diagnosis of HT undergoing simultaneous bilateral TKA procedure, no significant difference was observed in the decrease of hemoglobin level and number of blood units transfused between patients who received IA TXA in comparison to those who did not receive TXA.

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What Is the Benefit of Tranexamic Acid vs Reinfusion Drains in Total Joint Arthroplasty?

Cited by 19 publications

References 34 publications

No benefit of autologous transfusion drains in total knee arthroplasty

No benefit of autologous transfusion drains in total knee arthroplasty

Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia

Evaluation of the efficacy of intra-articular tranexamic acid in patients with hypertension undergoing simultaneous bilateral total knee arthroplasty

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