What is optimal timing of warming for transferring vitrified cleavage stage of day 3 slow-growing embryos? A cohort retrospective study

Geng, Lan; Wu, Jiahui; Luo, Jieting; Liu, Rang; Li, Junsheng; Shi, Yu; Kallen, Amanda N.; Wang, Tianren; Xia, Xi

doi:10.1007/s00404-021-06321-2

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“…The synchrony between embryo maturation and endometrial development, which are two independent events, is a crucial factor for successful implantation. It was reported that a lower implantation rate may result when there is a time difference between the slow growth of the embryo and the accelerated endometrium decidualization [ 27 , 28 ]. In the current study, further overnight culture once the two embryos reach eight cells may correct the synchrony between the embryo and the endometrium, and thus result in relatively satisfactory pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcome of Day-3 Cleavage Slow-Growing Embryos at Different Cleavage Rates after Overnight Culture: A Cohort Retrospective Study

Geng

Lin²,

Liu³

et al. 2022

JCM

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Introduction: We explored the association between clinical outcomes and the cleavage rate of day-3 cleavage slow-growing embryos after overnight culture. Methods: The data collected from 303 frozen embryo transfer (FET) cycles with 606 4-cell or 5-cell embryos cultured overnight (18–22 h) after thawing were analyzed. Based on the growth rate after the overnight culture, the embryos were divided into three groups: no embryo reaching eight cells (Group I), either one of the two embryos reaching eight cells (Group II), and both two embryos reaching eight cells or more (Group III). A statistical analysis of the different clinical outcomes from the three groups was performed. Results: Biochemical pregnancy rate (OR 3.22; p = 0.001), implantation rate (OR 2.44; p = 0.002), clinical pregnancy rate (OR 3.04; p = 0.001), ongoing pregnancy rate (OR 3.14; p = 0.001), and live birth rate (OR 2.78; p = 0.004) were significantly higher in Group III as compared to Group I. Group II had a significantly higher biochemical pregnancy rate (OR 2.02; p = 0.013) and implantation rate (OR 1.77; p = 0.019) than Group I. Conclusions: The capability of day-3 cleavage slow-growing embryos to reach eight cells, especially that of two embryos reaching eight cells by overnight culture, appear to result in a better pregnancy outcome.

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Section: Discussionmentioning

confidence: 99%