What Is New With Omicron Variant of SARS-CoV-2 in Children?

Bittmann, Stefan; Luchter, Elisabeth; Moschüring-Alieva, Elena; Bittmann, Lara; Villalón, G. Vidal

doi:10.14740/jocmr4671

Cited by 3 publications

(5 citation statements)

References 9 publications

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“…[ [1] , [2] , [3] ] The omicron VOC contains up to 36 mutations in spike protein and has been speculated to differ from previous VOCs not only in infectivity but also in clinical manifestations. [ 2 , 4 ]…”

Section: Introductionmentioning

confidence: 99%

“…The omicron strain (BA.1/B.1.1.529) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a variant of concern (VOC); it is more transmissible than previous VOCs and has spread rapidly worldwide [1][2][3]. The omicron VOC contains up to 36 mutations in spike protein and has been speculated to differ from previous VOCs not only in infectivity but also in clinical manifestations [2,4].…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of pediatric patients with COVID-19 between Omicron era vs. pre-Omicron era

Iijima

Kubota

Ogimi

2022

Journal of Infection and Chemotherapy

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of pediatric patients with COVID-19 between Omicron era vs. pre-Omicron era

Iijima

Kubota

Ogimi

2022

Journal of Infection and Chemotherapy

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“…Omicron is associated with higher transmissibility and less severe COVID-19 outcomes. 13 14 Furthermore, this SARS-CoV-2 variant can infect people of all ages, including newborns. 15 The majority of Omicron-infected individuals are asymptomatic or have mild symptoms.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing viral shedding time in non-severe paediatric infection with the SARS-CoV-2: a single-centre retrospective study

Hong,

li,

Tian

et al. 2023

bmjpo

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BackgroundThe aim of this study was to determine the factors influencing viral shedding time (VST) in non-severe paediatric infection with SARS-CoV-2).MethodsWe conducted a retrospective analysis of data from 240 non-severe paediatric infection with the SARS-CoV-2. Multivariate Cox regression analysis was used to identify independent predictors associated with VST.ResultsTwo hundred and forty patients were included in the study. The median duration of VST was 10 days (IQR, 8–13 days). Compared with patients aged <1 year, children aged 6–12 years (adjusted HR (aHR): 1.849; 95% CI 1.031 to 3.315) and >12 years (aHR: 2.180; 95% CI 1.071 to 4.439) had shorter VST. Non-leucopenia patients (aHR: 1.431; 95% CI 1.005 to 2.038) also had a lower VST.DiscussionThe results of this study show that children aged <1 year and children with leucopenia had longer SARS-CoV-2 VST. These factors should be taken into account when developing policies for the isolation of patients with COVID-19.

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“…It is known that, in contrast to previous variants, the Omicron variant affects all age groups, including the youngest [39,40]. The "seven-day incidence indicator" that describes the number of infections within 7 days per 100,000 inhabitants is currently the highest among the 5-14-year-old age group [39]. Similarly, according to the CDC, the number of young children hospitalized in the U.S.A. due to COVID-19 is rising; however, it is reasonable to say that many children who tested positive for SARS-CoV-2 are currently coming to hospitals with other respiratory illnesses [8].…”

Section: Clinical Manifestations and Diagnosismentioning

confidence: 96%

“…Interestingly, BA.2 infection has a shorter average time from symptom onset, as demonstrated by contact tracing data: the mean onset interval is around half a day shorter for BA.2 than BA.1 (3.27 days for BA.2, 3.72 days for BA.1, and 4.09 days for Delta) [8]. It is known that, in contrast to previous variants, the Omicron variant affects all age groups, including the youngest [39,40]. The "seven-day incidence indicator" that describes the number of infections within 7 days per 100,000 inhabitants is currently the highest among the 5-14-year-old age group [39].…”

Section: Clinical Manifestations and Diagnosismentioning

confidence: 99%

Omicron BA.2 Lineage, the “Stealth” Variant: Is It Truly a Silent Epidemic? A Literature Review

Tiecco

Storti

Arsuffi

et al. 2022

IJMS

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The epidemic curve of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is silently rising again. Worldwide, the dominant SARS-CoV-2 variant of concern (VOC) is Omicron, and its virological characteristics, such as transmissibility, pathogenicity, and resistance to both vaccine- and infection-induced immunity as well as antiviral drugs, are an urgent public health concern. The Omicron variant has five major sub-lineages; as of February 2022, the BA.2 lineage has been detected in several European and Asian countries, becoming the predominant variant and the real antagonist of the ongoing surge. Hence, although global attention is currently focused on dramatic, historically significant events and the multi-country monkeypox outbreak, this new epidemic is unlikely to fade away in silence. Many aspects of this lineage are still unclear and controversial, but its apparent replication advantage and higher transmissibility, as well as its ability to escape neutralizing antibodies induced by vaccination and previous infection, are rising global concerns. Herein, we review the latest publications and the most recent available literature on the BA.2 lineage of the Omicron variant.

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What Is New With Omicron Variant of SARS-CoV-2 in Children?

Cited by 3 publications

References 9 publications

Clinical characteristics of pediatric patients with COVID-19 between Omicron era vs. pre-Omicron era

Clinical characteristics of pediatric patients with COVID-19 between Omicron era vs. pre-Omicron era

Factors influencing viral shedding time in non-severe paediatric infection with the SARS-CoV-2: a single-centre retrospective study

Omicron BA.2 Lineage, the “Stealth” Variant: Is It Truly a Silent Epidemic? A Literature Review

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