What Is New in Infectious Diseases?

Cook, Paul P.

doi:10.18043/ncm.77.5.320

Cited by 3 publications

(2 citation statements)

References 32 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Infectious diseases have shaped human history, and the themes of this field are never repeated. In the modern era, tuberculosis (TB) is the leading cause of morbidity and mortality due to infectious diseases (44)(45)(46). Although the first anti-tuberculosis drugs were discovered 60 years ago, it is still a health issue, with 8.8 million cases and 1.7 million deaths annually (47).…”

Section: Clinical Implications: Mobile Self-care System For Tuberculosis Controlmentioning

confidence: 99%

Intelligent Alarm System-Based Devices Designed for People with Disabilities, Caused by Various Chronic Diseases

Tirdad

Nami

Samieyan

et al. 2021

Jundishapur J Chronic Dis Care

View full text Add to dashboard Cite

Context: Chronic diseases (CD) are defined as symptoms or disabilities, caused by diseases, genetic factors, and injury requiring long-term treatment. Intelligent alarm systems, which collect patient health data and transfer it to a medical server, help track and avoid future incidents. Method: The search terms were “computer network” OR “information systems” OR “wireless technology” OR “decision support systems” AND “chronic disease” OR “chronic disease” in major electronic databases, including Pubmed/Medline, Scopus, Embase, ISI Web of Science, and Cochrane Central. Results: The search resulted in 1275 articles with 11 specific to intelligence-based systems in chronic medical conditions until 08 June 2021. The creation of different access levels for care providers in the system and application customization according to CD conditions were the goals that can be achieved in future research. The human-computer interface (HCI) systems, smart home, and software, such as Fitbit using IoMT to monitor health metrics in people with different CDs, are introduced so far. Conclusions: These systems, if provided on the web and mobile platform, can be accessed at any time and place and are more efficient. Finally, the combination of clinical decision support systems with artificial intelligence has beneficial effects on physician's systems, increases the accuracy in CD diagnosis, and improves the pain management. This intelligent system demonstrates factors influencing back to work and allows identifying high-risk patients and their potential to handle activities of daily living.

show abstract

Section: Clinical Implications: Mobile Self-care System For Tuberculosis Controlmentioning

confidence: 99%

Intelligent Alarm System-Based Devices Designed for People with Disabilities, Caused by Various Chronic Diseases

Tirdad

Nami

Samieyan

et al. 2021

Jundishapur J Chronic Dis Care

View full text Add to dashboard Cite

show abstract

“…Despite the fact that the WHO does not consider malaria, tuberculosis and zika virus as NTDs, they dramatically affect lower-income populations in countries located in tropical regions. Therefore, every year, these illnesses cost billions of dollars to such regions economy, leading to a vicious cycle of poverty [2,3]. As regards to therapies, the drugs currently employed have debateable effectiveness and exhibit high cytotoxicity, revealing an urgent need for new ones [1,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Neglected tropical diseases and infectious illnesses: potential targeted peptides employed as hits compounds in drug design

Silva

Santos

Miranda

et al. 2020

Journal of Drug Targeting

View full text Add to dashboard Cite

Neglected Tropical Diseases (NTDs) and infectious illnesses, such as malaria, tuberculosis and Zika fever, represent a major public health concern in many countries and regions worldwide, especially in developing ones. They cause thousands of deaths per year, and certainly compromise the life of affected patients. The drugs available for therapy are toxic, have considerable adverse effects, and are obsolete, especially with respect to resistance. In this context, targeted peptides are considered promising in the design of new drugs, since they have specific action and reduced toxicity. Indeed, there is a rising interest in these targeted compounds within the pharmaceutical industry, proving their importance to the Pharmaceutical Sciences field. Many have been approved by the Food and Drug Administration (FDA) to be used as medicines, plus there are more than 300 peptides currently in clinical trials. The main purpose of this review is to show the most promising potential targeted peptides acting as hits molecules in NTDs and other infectious illnesses. We hope to contribute to the discovery of medicines in this relatively neglected area, which will be extremely useful in improving the health of many suffering people.

show abstract

Amazon Rainforest: A Natural Source for New Therapeutic Alternatives against Neglected Tropical Diseases

Santos

Silva

Boniface

et al. 2022

NPJ

View full text Add to dashboard Cite

The Amazon rainforest has wide and unique biodiversity, which is an important source of natural products for the development of drugs. Neglected tropical diseases (NTDs) represent a major health problem as they affect over 1 billion people, especially vulnerable populations living in tropical and subtropical regions. Currently available drugs are generally inadequate for the majority of these diseases, thus, there is an urgent need for new treatments. The present review aims to summarize up-to-date and comprehensive information on the efficacy of the Amazon plants, about treating certain neglected tropical diseases. According to the literature information, several compounds (phenolics, alkaloids, terpenoids and steroids, among others) which were isolated from plants of the Amazon forest showed in vitro activity against Leishmania sp., Trypanosoma cruzi, the parasites responsible for leishmaniasis and Chagas disease, respectively. Moreover, extracts, and essential oil from certain plants were reported to have mosquito repellent and insecticidal activities against Aedes aegypti, the vector of dengue, and chikungunya. This review demonstrated that the Amazonian rainforest is endowed with pharmacologically active plants which can be used as a starting point for the development of new drugs against NTDs, such as leishmaniasis, Chagas disease, dengue, chikungunya.

show abstract

What Is New in Infectious Diseases?

Cited by 3 publications

References 32 publications

Intelligent Alarm System-Based Devices Designed for People with Disabilities, Caused by Various Chronic Diseases

Intelligent Alarm System-Based Devices Designed for People with Disabilities, Caused by Various Chronic Diseases

Neglected tropical diseases and infectious illnesses: potential targeted peptides employed as hits compounds in drug design

Amazon Rainforest: A Natural Source for New Therapeutic Alternatives against Neglected Tropical Diseases

Contact Info

Product

Resources

About