What is Needed for Evidence‐Based Dietary Recommendations for Migraine: A Call to Action for Nutrition and Microbiome Research

Slavin, Margaret; Li, Huilun Amber; Frankenfeld, Cara L.

doi:10.1111/head.13658

Cited by 26 publications

(22 citation statements)

References 131 publications

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“…A clear relation between gut microbiota and migraine is still to be established; however, its impact on the central and peripheral nervous systems supports a role in the migraine physiopathology. [25] Nevertheless, the HEP score did not increase significantly in the responder group, suggesting that the different items contributing to calculate the HEP score did not have the same impact on migraine (see Table 5).…”

Section: Discussionmentioning

confidence: 94%

The Healthy Eating Plate advice for Migraine prevention: an interventional study

Altamura

Cecchi

Bravo

et al. 2020

Preprint

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Background: migraine is a chronic neurological disorder with a high social impact. Several diets have been proposed to help managing migraine, with different outcomes. We aimed at evaluating the effect of education on the Healthy Eating Plate on migraine frequency and disability.Methods: 240 consecutive people with migraine (18 – 72-year old, 84.5% female) were screened for participation in this interventional study. Migraine was diagnosed according to the International Classification of Headache Disorders. At three times of observation (screening = T-12, 12 weeks before the intervention; baseline = T0, time of educational intervention; and follow-up = T12, after 12 weeks from baseline) the enrolled people affected by migraine underwent anthropometric measurement, dietary patterns assessment, and migraine frequency and related disability evaluation (MIDAS, MIDAS A, MIDAS B). At T0 all enrolled people were educated about the Healthy Eating Plate by a nutritionist. The Healthy Eating Plate score was created to assess adherence to the dietary advice.Results; 204 people with migraine were enrolled in the study, of these 119 people were still eligible at T0 while 97 people completed the evaluations at T12. From T0 to T12 we observed a reduction in body mass index and in monthly migraine days in the three months before the last evaluation (MIDAS A). People presenting a reduction of at least 30% in monthly migraine days were classified as responders. Responders significantly presented a reduction in red and processed meats and carb intake compared with non-responders. In addition, the Healthy Eating Plate scores were significantly higher in responders compared to non-responders, while no difference was observed for body mass index. The modification in carb consumption was also related to the variation in perceived disability (MIDAS score, ρ = 0.372 with p <0.0001) and in headache pain intensity (MIDAS B, ρ = 0.220, p=0.033). Binary logistic regression confirmed the main effect of the Healthy Eating Plate score increase and total carb decrease on the responder state.Conclusions This longitudinal study showed that adherence to the healthy eating plate advice, particularly the indication to reduce carb and red and processed meat consumption, is useful in migraine management, reducing monthly migraine days and disability.Trial registration: ISRCTN, ISRCTN14092914. Registered 14 February 2020 - Retrospectively registered, http://www.isrctn.com/ISRCTN14092914

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Section: Discussionmentioning

confidence: 94%

The Healthy Eating Plate advice for Migraine prevention: an interventional study

Altamura

Cecchi

Bravo

et al. 2020

Preprint

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“…Research on the microbiome and migraine is still young, and further investigation is required before recommending a dietary intervention intended to change the microbiome for preventing migraine [ 75 ]. However, a similar approach might be useful here for the determination of individual differences toward personalized nutritional recommendations.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, obesity control and weight loss programs may exert different outcomes in different subpopulations of migraine patients, depending on several factors, including age and sex. A recent paper [ 75 ] presented an overview of the strength of existing evidence for food-based dietary interventions for migraine and called for high-quality dietary and microbiome research in migraine, both to substantiate the hypothesized relationships and to build up evidence-based information regarding the impact of nutritional interventions on migraine.…”

Section: Gut–brain Axis and Probioticsmentioning

confidence: 99%

Migraine and Diet

Gazerani

2020

Nutrients

128

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Migraine is characterized by recurrent attacks of disabling headaches, often accompanied by sensory and motor disturbances. Clinical manifestations of migraine are influenced by dietary behaviors and dietary elements. Several dietary triggers for migraine have been identified, leading to the definition of strategies such as elimination diets, ketogenic diets, and comprehensive diets, mainly to help prevent migraine. Although inconsistency is present in the literature and no consensus exists, the available data are promising in supporting beneficial dietary interventions for some migraine patients. Several factors influence the net outcome, including age, sex, genetics, and environmental factors. Advancement in understanding the underlying mechanisms of migraine pathogenesis and how dietary factors can interfere with those mechanisms has encouraged investigators to consider diet as a disease-modifying agent, which may also interfere with the gut–brain axis or the epigenetics of migraine. Future work holds potential for phenotyping migraine patients and offering personalized recommendations in line with biopsychosocial models for the management of migraine. Diet, as an important element of lifestyle, is a modifiable aspect that needs further attention. Well-designed, systematic, and mechanism-driven dietary research is needed to provide evidence-based dietary recommendations specific to migraine. This narrative review aims to present the current status and future perspective on diet and migraine, in order to stimulate further research and awareness.

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“…It has been implied in a variety of neurological and psychiatric disorders. A clear relation between gut microbiota and migraine is still to be established; however, its impact on the central and peripheral nervous systems supports a role in the migraine physiopathology [28].…”

Section: Discussionmentioning

confidence: 99%

The Healthy Eating Plate Advice for Migraine Prevention: An Interventional Study

et al. 2020

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We aimed at evaluating the effect of the Healthy Eating Plate (HEP) education on migraine frequency and disability. At three evaluation times (T-12 = screening, 12 weeks before the intervention; T0 = time of the educational HEP intervention; and T12 = 12-week follow-up), the enrolled subjects underwent assessment of anthropometric and dietary patterns, monthly migraine days (MMDs), and disability scales (Migraine Disability Assessment score (MIDAS), MIDAS A, MIDAS B). The HEP score estimated adherence to dietary advice. We enrolled 204 out of 240 screened migraineurs, of these, 97 patients completed the follow-up. We defined ADHERENTS as patients presenting an increase in HEP scores from T0 to T12 and RESPONDERS as those with a reduction of at least 30% in MMDs. ADHERENTS presented a significant decrease in MMDs from T0 to T12. In particular, RESPONDERS reduced red, processed meat and carb intake compared to NON-RESPONDERS. Reduction in carb consumption also related to a decrease in perceived disability (MIDAS) and headache pain intensity (MIDAS B). Logistic regression confirmed that the HEP score increase and total carb decrease were related to a reduction in MMDs. This study showed that adherence to the HEP advice, particularly the reduction in carb, red and processed meat consumption, is useful in migraine management, reducing migraine frequency and disability. Trial registration: ISRCTN14092914.

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What is Needed for Evidence‐Based Dietary Recommendations for Migraine: A Call to Action for Nutrition and Microbiome Research

Cited by 26 publications

References 131 publications

The Healthy Eating Plate advice for Migraine prevention: an interventional study

The Healthy Eating Plate advice for Migraine prevention: an interventional study

Migraine and Diet

The Healthy Eating Plate Advice for Migraine Prevention: An Interventional Study

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