What Is High Enough? Elevated NT-pro-BNP in Decompensated Paroxysmal Supraventricular Tachycardia

Reeves, Shawn; Womack, C.; Lutherer, L. O.; Todd, Christopher; Pinkney, Kerrie A.; Kasemsri, Thivakorn

doi:10.1055/s-0037-1603760

Cited by 3 publications

References 23 publications

(19 reference statements)

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Rediscover the predictive capacity of B-type natriuretic peptide applied to neonatal supraventricular tachycardia

Lu,

Xiong,

Wen

et al. 2023

BMC Cardiovasc Disord

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Background Supraventricular tachycardia (SVT) is one of the most common non-benign arrhythmias in neonates, potentially leading to cardiac decompensation. This study investigated the early risk factors of acute heart failure (AHF) secondary to SVT in neonates, and explored their value in guiding the selection of effective anti-arrhythmic treatment. Methods A total of 43 newborns diagnosed with and treated for SVT between January 2017 and December 2022 were analyzed. According to the presence of AHF after restoring sinus rhythm in newborns with SVT, they were divided into SVT with AHF group and SVT without AHF group. Clinical data and anti-arrhythmic therapies were analyzed. Risk factors of AHF secondary to SVT in neonates were determined using logistic regression. The cut-off value for predictors of AHF secondary to SVT and demanding of a second-line anti-arrhythmic treatment was determined through receiver operating characteristic (ROC) analysis. Results Time to initial control of tachycardia > 24 h, hyperkalemia, anemia, and plasma B-type natriuretic peptide (BNP) were identified as risk factors of AHF secondary to SVT in neonates. BNP exhibited AUC of 0.80 in predicting AHF, and BNP > 2460.5pg/ml (OR 2.28, 95% CI 1.27 ~ 45.39, P = 0.03) was an independent predictor, yielding sensitivity of 70.6% and specificity of 84.6%. Neonates with BNP > 2460.5pg/ml (37.5% versus 7.4%, P = 0.04) had a higher demand for a second line anti-arrhythmic treatment to terminate SVT, with sensitivity and specificity for BNP in predicting at 75.0%, 71.4%, respectively. Conclusions BNP could be used to predict an incident of AHF secondary to SVT and a demand of second-line anti-arrhythmic treatment to promptly terminate SVT and prevent decompensation in neonates.

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Rediscover the predictive capacity of B-type natriuretic peptide applied to neonatal supraventricular tachycardia

Lu,

Xiong,

Wen

et al. 2023

BMC Cardiovasc Disord

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Rediscover the predictive capacity of B-type natriuretic peptide applied to neonatal ventricular supertachycardia

Lü

Xiong

Wen

et al. 2023

Preprint

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Background Supraventricular tachycardia (SVT) is one of the most common non-benign arrhythmias in neonates that could lead to cardiac decompensation. This study investigated early risk factors of acute heart failure (AHF) secondary to SVT in neonates, and explored their value on guiding the selection of efficient anti-arrhythmic treatment. Methods A total of 43 newborns with SVT diagnosed and treated between January 2017 and December 2022 were analyzed. According to the presence of AHF after initial restoring SVT to sinus rhythm, newborns were divided into SVT with AHF group and SVT without AHF group, and the clinical data and anti-arrhythmic therapies were analyzed. Risk factors of AHF secondary to SVT in neonates were determined by logistic regression. The cut-off value for predictors of AHF secondary to SVT and demanding of a second line anti-arrhythmic treatment was determined by receiver operating characteristic curve analysis. Results Time to initial control of tachycardia > 24h, hyperkalemia, anemia, plasma B-type natriuretic peptide (BNP) were risk factors of AHF secondary to SVT in neonates. BNP exhibited AUC of 0.804 in predicting AHF, and BNP > 2460.5pg/ml (OR 2.281, 95% CI 1.270 ~ 45.399, P = 0.026) was an independent predictor yielded sensitivity of 70.59% and specificity of 84.62%. The neonates with BNP > 2460.5pg/ml (37.5% versus 7.4%, P = 0.037) had a higher demand for a second line anti-arrhythmic treatment to terminate SVT, and the sensitivity and and specificity for BNP in predicting were 75.0%, 71.4%, respectively. Conclusions BNP could be used to predict an incident of AHF secondary to SVT and a demand of second line anti-arrhythmic treatment for terminating SVT hastily to prevent decompensation in neonates.

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Exercise-Induced Hyponatremia: An Assessment of the International Hydration Recommendations Followed During the Gran Trail De Peñalara and Vitoria-Gasteiz Ironman Competitions

et al. 2022

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IntroductionHyponatremia often occurs during the practice of endurance sports. We evaluated the impact on hyponatremia of the hydration recommendations of the Third International Exercise-Associated Hyponatremia Consensus Development Conference 2015 (3IE-AHCD) during the 2017 Gran Trail de Peñalara marathon (GTP) and the Vitoria Gasteiz Ironman triathlon (VGI).MethodsProspective study of GTP and VGI athletes participating in four information sessions in the months prior to the events, to explain that hydration should only be according to their level of thirst, per the recommendations of the 3IE-AHCD. Consenting event finishers were included in final analysis. Pre- and post-race anthropometric and biochemical parameters were compared.ResultsThirty-six GTP (33 male) and 94 VGI (88 male) finishers were evaluated. GTP race median fluid intake was 800 ml/h, with 900 ml/h in the VGI race. 83.3% GTPfin and 77.6% VGIfin remained eunatremic (blood sodium 135–145 mmol/L). Only 1/36 GTP and 1/94 VGI participant finished in hyponatremia, both with a sodium level of 134 mmol/L. Fourteen percent of GTP, and 21.2% of VGI participants finished in hypernatremia, with no increase in race completion times. No participating athlete required medical attention, except for musculoskeletal complaints. Pro-BNP and Copeptin levels rose significantly. Changes in copeptin levels did not correlate with changes in plasma osmolality, nor total body water content in impedance analysis.ConclusionsRecommending that athletes' fluid intake in endurance events be a function of their thirst almost entirely prevented development of hyponatremia, without induction of clinically significant hypernatremia, or a negative repercussion on race completion times.

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What Is High Enough? Elevated NT-pro-BNP in Decompensated Paroxysmal Supraventricular Tachycardia

Cited by 3 publications

References 23 publications

Rediscover the predictive capacity of B-type natriuretic peptide applied to neonatal supraventricular tachycardia

Rediscover the predictive capacity of B-type natriuretic peptide applied to neonatal supraventricular tachycardia

Rediscover the predictive capacity of B-type natriuretic peptide applied to neonatal ventricular supertachycardia

Exercise-Induced Hyponatremia: An Assessment of the International Hydration Recommendations Followed During the Gran Trail De Peñalara and Vitoria-Gasteiz Ironman Competitions

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