Background
Hematuria is a common clinical finding and represents the most frequent presenting sign of bladder cancer. The American Urological Association recommends cystoscopy and abdomino-pelvic imaging for patients over 35 years. Nonetheless, fewer than half of patients presenting with hematuria undergo proper evaluation. We sought to identify clinical and non-clinical factors associated with evaluation of persons with newly diagnosed hematuria.
Methods
Retrospective cohort study, using claims data and laboratory values. The primary exposure was practice site, as a surrogate for non-clinical, potentially modifiable sources of variation. Primary outcomes were cystoscopy and/or abdomino-pelvic imaging within 180 days following hematuria diagnosis. We modeled the association between clinical and non-clinical factors and appropriate hematuria evaluation.
Results
We identified 2,455 primary care patients 40 years of age or older diagnosed with hematuria between 2004 and 2012 in the absence of other explanatory diagnosis. 13.7% of patients underwent cystoscopy within 180 days. Multivariate logistic regression revealed significant variation between those who did and did not undergo evaluation in age, gender and anti-coagulant use (p<0.001, p=0.036, p=0.028). Addition of practice site improved the predictive discrimination of each model (p<0.001). Evaluation was associated with higher rates of genitourinary neoplasia diagnosis.
Conclusions
Patients with hematuria rarely underwent complete evaluation. While established risk factors for malignancy were associated with increasing use of diagnostic testing, factors unassociated with risk, such as practice site, also accounted for significant variation. Inconsistency across practice sites is undesirable and may be amenable to quality improvement interventions.