What is changing in indications and treatment of hepatic hemangiomas. A review

Toro, Adriana; Mahfouz, Ahmed; Ardiri, Annalisa; Malaguarnera, Michele; Malaguarnera, Giulia; Loria, Francesco; Bertino, Gaetano; Carlo, Isidoro Di

doi:10.1016/s1665-2681(19)30839-7

Cited by 149 publications

(141 citation statements)

References 90 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…Giant cavernous haemangiomas (>4 cm) are more likely to be symptomatic, with patients typically presenting with abdominal pain and/or fullness,1 as was present in this case. While surgical resection remains the definitive curative treatment, other treatments exist for unresectable lesions in the form of liver transplantation, transcatheter arterial embolisation (TAE), arterial ligation and chemotherapy 1…”

Section: Introductionmentioning

confidence: 61%

See 1 more Smart Citation

Same day arterial embolisation followed by hepatic resection for treatment of giant haemangioma

et al. 2016

View full text Add to dashboard Cite

Cavernous haemangiomas are the most common tumour of the liver; they are benign in nature and have an incidence of up to 7.3% at autopsy. Occasionally, they may cause symptoms necessitating intervention. We report the case of a woman who presented with non-specific abdominal pain and evidence of a giant hepatic haemangioma on abdominal imaging. She underwent selective hepatic arteriography with transcatheter arterial embolisation followed by same-day left hemi-hepatectomy, making an uneventful recovery. We discuss the management of giant hepatic haemangiomas and present same day transcatheter arterial embolisation prior to hepatic resection as a safe and viable treatment strategy in selected cases.

show abstract

Section: Introductionmentioning

confidence: 61%

“…Cavernous haemangiomas are the most common benign liver tumours, representing 73% of all benign hepatic lesions, and have an incidence of 0.4–7.3% at autopsy 1. Haemangiomas are mesoderm-derived tumours consisting of cavernous vascular spaces lined by dysfunctional endothelial cell layers, separated by fibrous septae 2.…”

Section: Introductionmentioning

confidence: 99%

Same day arterial embolisation followed by hepatic resection for treatment of giant haemangioma

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Several studies have examined the natural course of hepatic hemangioma, and reported that the vast majority of hepatic hemangiomas remain stable in size . However, previous studies suffered from limitations regarding the number of lesions, the length of follow up and the inclusion of cases with heterogeneous features.…”

Section: Discussionmentioning

confidence: 99%

“…S EVERAL STUDIES HAVE examined the natural course of hepatic hemangioma, and reported that the vast majority Natural history of hepatic hemangioma 729 Hepatology Research 2016 of hepatic hemangiomas remain stable in size. [10][11][12][13][14] However, previous studies suffered from limitations regarding the number of lesions, the length of follow up and the inclusion of cases with heterogeneous features. The present study is one of the very few studies with a large series which was performed especially to investigate the natural history of hepatic hemangiomas.…”

Section: Discussionmentioning

confidence: 99%

New recognition of the natural history and growth pattern of hepatic hemangioma in adults

Huang

Liu

et al. 2016

Hepatology Research

View full text Add to dashboard Cite

show abstract

“…This phenotype was not observed in the livers of control mice (Figure 1(c), left) or LRRK2 − / − mice without the liver growths (BW and LM, unpublished observations). The gross morphology and the microscopic structure of the liver growths are similar to the characteristics of hepatic hemangiomas [17], a benign tumor composed of hepatic endothelial cells [18]. …”

Section: Resultsmentioning

confidence: 99%

Altered Expression ofEPOMight Underlie Hepatic Hemangiomas inLRRK2Knockout Mice

Xiao

Zhang

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

Parkinson's disease (PD) is a severe neurodegenerative disorder caused by progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. The molecular mechanism of PD pathogenesis is unclear. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common genetic cause of familial and sporadic PD. However, studies on LRRK2 mutant mice revealed no visible dopaminergic neuronal loss in the midbrain. While surveying a LRRK2 knockout mouse strain, we found that old animals developed age-dependent hepatic vascular growths similar to cavernous hemangiomas. In livers of these hemangioma-positive LRRK2 knockout mice, we detected an increased expression of the HIF-2α protein and significant reactivation of the expression of the HIF-2α target gene erythropoietin (EPO), a finding consistent with a role of the HIF-2α pathway in blood vessel vascularization. We also found that the kidney EPO expression was reduced to 20% of the wild-type level in 18-month-old LRRK2 knockout mice. Unexpectedly, this reduction was restored to wild-type levels when the knockout mice were 22 months to 23 months old, implying a feedback mechanism regulating kidney EPO expression. Our findings reveal a novel function of LRRK2 in regulating EPO expression and imply a potentially novel relationship between PD genes and hematopoiesis.

show abstract

What is changing in indications and treatment of hepatic hemangiomas. A review

Cited by 149 publications

References 90 publications

Same day arterial embolisation followed by hepatic resection for treatment of giant haemangioma

Same day arterial embolisation followed by hepatic resection for treatment of giant haemangioma

New recognition of the natural history and growth pattern of hepatic hemangioma in adults

Altered Expression ofEPOMight Underlie Hepatic Hemangiomas inLRRK2Knockout Mice

Contact Info

Product

Resources

About